{"id":4550,"date":"2025-03-31T18:12:12","date_gmt":"2025-03-31T18:12:12","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ivabradine-hydrochloride-txt\/"},"modified":"2025-03-31T18:12:12","modified_gmt":"2025-03-31T18:12:12","slug":"ivabradine-hydrochloride-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ivabradine-hydrochloride-txt\/","title":{"rendered":"ivabradine hydrochloride.txt"},"content":{"rendered":"

ivabradine hydrochloride <\/h1>\n

CLINICAL USE <\/H3>
\nSymptomatic treatment of chronic stable angina pectoris in patients with sinus rhythm, if beta-blockers are contraindicated

DOSE IN NORMAL RENAL FUNCTION <\/H3>2.5\u20137.5 mg twice daily (dose is reduced if heart rate is consistently below 50 beats per minute)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :504.5<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :70<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 4<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :100 litres<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function15\u201320 Dose as in normal renal function<15 Dose as in normal renal function. Use with caution

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in GFR<15 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in GFR<15 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR<15 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone and disopyramide\n
  • Antibacterials: concentration possibly increased by clarithromycin and telithromycin \u2013 avoid concomitant use; increased risk of ventricular arrhythmias with erythromycin \u2013 avoid concomitant use\n
  • Antifungals: concentration increased by ketoconazole \u2013 avoid concomitant use; concentration increased by fluconazole \u2013 reduce initial ivabradine dose; concentration possibly increased by itraconazole \u2013 avoid concomitant use\n
  • Antimalarials: increased risk of ventricular arrhythmias with mefloquine\n
  • Antipsychotics: increased risk of ventricular arrhythmias with pimozide or sertindole\n
  • Antivirals: concentration possibly increased by nelfinavir and ritonavir \u2013 avoid concomitant use\n
  • Beta-blockers: increased risk of ventricular arrhythmias with sotalol\n
  • Calcium-channel blockers: concentration increased by diltiazem and verapamil \u2013 avoid concomitant use\n
  • Grapefruit juice: ivabradine concentration increased\n
  • Pentamidine: increased risk of ventricular arrhythmiasSt John\u2019s wort: ivabradine concentration reduced \u2013 avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013ivabradine hydrochloride
    \n","protected":false},"excerpt":{"rendered":"

    ivabradine hydrochloride CLINICAL USE Symptomatic treatment of chronic stable angina<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4550","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4550","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4550"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4550\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}