{"id":4545,"date":"2025-03-31T18:12:12","date_gmt":"2025-03-31T18:12:12","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/isosorbide-dinitrate-txt\/"},"modified":"2025-03-31T18:12:12","modified_gmt":"2025-03-31T18:12:12","slug":"isosorbide-dinitrate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/isosorbide-dinitrate-txt\/","title":{"rendered":"isosorbide dinitrate .txt"},"content":{"rendered":"

isosorbide dinitrate <\/h1>\n

CLINICAL USE <\/H3>
\nVasodilator:Prophylaxis and treatment of angina Left ventricular failure

DOSE IN NORMAL RENAL FUNCTION <\/H3>Oral: Angina: 30\u2013120 mg daily in divided \u2014doses;LVF: 40\u2013 240 mg daily \u2014IV: 2\u201320 mg\/hour depending on response

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :236.1<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :<1<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp :
  • 10 to 20 &nbsp &nbsp :<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :2\u20134<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :0.5\u20131\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsSildenafil: hypotensive effect significantly enhanced \u2013 avoid concomitant useTadalafil: hypotensive effect significantly enhanced \u2013 avoid concomitant use\n
  • Vardenafil: hypotensive effect significantly enhanced \u2013 avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral,

    IV infusion <\/H4>

    Rate of Administration <\/H4>1 mg\/10 mL; 60 mL\/hour \u2261 6 mg\/hour2 mg\/10 mL; 30 mL\/hour \u2261 6 mg\/hour

    Comments<\/H4>Dilute using sodium chloride 0.9% or glucose 5% to 1 mg\/10 mL or 2 mg\/10 mL; final volume 500 mLUse of PVC giving sets and containers should be avoided since significant losses of the active ingredient by absorption can occur

    OTHER INFORMATION <\/H4>Isosorbide dinitrate undergoes extensive first pass metabolism, mainly in the liver; major metabolites are isosorbide-2-mononitrate and isosorbide-5-mononitrateBoth metabolites possess vasodilatory activity and may contribute to the activity of the parent compoundBoth metabolites have longer half-lives than the parent compound
    \n","protected":false},"excerpt":{"rendered":"

    isosorbide dinitrate CLINICAL USE Vasodilator:Prophylaxis and treatment of angina Left<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4545","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4545"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4545\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}