{"id":4542,"date":"2025-03-31T18:12:11","date_gmt":"2025-03-31T18:12:11","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/iron-dextran-txt\/"},"modified":"2025-03-31T18:12:11","modified_gmt":"2025-03-31T18:12:11","slug":"iron-dextran-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/iron-dextran-txt\/","title":{"rendered":"iron dextran .txt"},"content":{"rendered":"

iron dextran 5% <\/h1>\n

CLINICAL USE <\/H3>
\nProphylaxis of iron deficiency anaemia (when oral treatment is ineffective or contraindicated) Treatment of iron deficiency during epoetin therapy especially if serum ferritin is very low (<50 nanograms\/mL)

DOSE IN NORMAL RENAL FUNCTION <\/H3>Total iron infusion: Dose of iron dextran (mg) = weight (kg) \u00d7 [Target Hb (g\/L) \u2013 Actual Hb (g\/L)] \u00d7 0.24 + 500 mg iron for iron stores (if body weight >35 kg) 20 mg\/kg in a single doseTarget haemoglobin level (110 g\/L for renal patients as a guide)or100\u2013200 mg 2 or 3 times a week depending on haemoglobinA test dose is essential. Give 0.5 mL or 25 mg iron over 15 minutes and observe for 60 minutes (15 minutes if using low dose bolus) for anaphylaxis. Have resuscitative equipment and drugs at hand (adrenaline, chlorphenamine and hydrocortisone)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :165 000<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :0<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <0.2<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.031\u20130.055<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :5\u201320\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Not dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsDimercaprol: avoid concomitant use Oral iron: reduced absorption of oral iron

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IV, IM

    Rate of Administration <\/H4>Infusion: 100 mL over 30 minutes Bolus: 10 mg\/minute Total dose infusion: over 4\u20136 hours; increase rate of infusion to 45\u201360 drops per minute

    Comments<\/H4>Infusion: 100\u2013200 mg in 100 mL sodium chloride or glucose 5%Bolus: add to
  • 10 to 20 &nbsp &nbsp : mL sodium chloride or glucose 5%Total dose infusion: add to 500 mL sodium chloride 0.9% or glucose 5%Keep under strict supervision during and for 1 hour after infusion

    OTHER INFORMATION <\/H4>Do not give to patients with history of asthmaIf patients with a history of allergy are prescribed iron dextran, give adequate antihistamine cover prior to administrationThe dose of iron dextran varies widely from 100 mg per dialysis session for 6\u201310 sessions, to single doses of 500 mg to 1 gThe incidence of anaphylaxis with the Cosmofer brand of iron dextran is significantly lower than with the old Imferon brand, since the iron is complexed to a much shorter dextran chain than was used previously
    \n","protected":false},"excerpt":{"rendered":"

    iron dextran 5% CLINICAL USE Prophylaxis of iron deficiency anaemia<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4542","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4542"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4542\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}