{"id":4535,"date":"2025-03-31T18:12:11","date_gmt":"2025-03-31T18:12:11","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/insulin-soluble-actrapid-or-humulin-s-txt\/"},"modified":"2025-03-31T18:12:11","modified_gmt":"2025-03-31T18:12:11","slug":"insulin-soluble-actrapid-or-humulin-s-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/insulin-soluble-actrapid-or-humulin-s-txt\/","title":{"rendered":"insulin soluble (Actrapid or humulin s).txt"},"content":{"rendered":"

insulin soluble (Actrapid or humulin s) <\/h1>\n

CLINICAL USE <\/H3>
\nHyperglycaemia, control of diabetes mellitusEmergency management of hyperkalaemia

DOSE IN NORMAL RENAL FUNCTION <\/H3>Variable

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :5808<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :5<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 0<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.15<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2\u20135\/13

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Variable
  • 10 to 20 &nbsp &nbsp : Variable
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Variable

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose according to clinical response<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose according to clinical response
  • HDF\/high flux &nbsp :Not dialysed. Dose according to clinical response
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose according to clinical response

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsFibrates: may improve glucose tolerance; additive effect with insulin

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IV via CRIP

    Rate of Administration <\/H4>Over 30 minutes or as required

    Comments<\/H4>Add 15\u201325 IU insulin to 50 mL 50% glucoseFor maintenance infusion or sliding scale infusion, add 50 IU insulin to 500 mL 10% glucose and adjust rate according to blood glucose levelsContinue infusing insulin\/glucose solution at rate of 10 mL\/hour according to serum potassium

    OTHER INFORMATION <\/H4>Monitor blood glucose Prior to insulin\/glucose infusion for hyperkalaemia, give IV 20 mL 10% calcium gluconate to protect myocardium and 50\u2013100 mL 8.4% sodium bicarbonate to correct acidosisCommence calcium resonium 15 g 4 times per day orallyInsulin is metabolised renally; therefore, requirements may be reduced in ERF
    \n","protected":false},"excerpt":{"rendered":"

    insulin soluble (Actrapid or humulin s) CLINICAL USE Hyperglycaemia, control<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4535","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4535"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4535\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}