{"id":4518,"date":"2025-03-31T18:12:11","date_gmt":"2025-03-31T18:12:11","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/hydroxychloroquine-sulphate-txt\/"},"modified":"2025-03-31T18:12:11","modified_gmt":"2025-03-31T18:12:11","slug":"hydroxychloroquine-sulphate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/hydroxychloroquine-sulphate-txt\/","title":{"rendered":"hydroxychloroquine sulphate.txt"},"content":{"rendered":"

hydroxychloroquine sulphate <\/h1>\n

CLINICAL USE <\/H3>
\nRheumatoid arthritis Systemic lupus erythematosus Dermatological conditions caused or aggravated by sunlightMalaria (unlicensed in UK)

DOSE IN NORMAL RENAL FUNCTION <\/H3>200\u2013400 mg daily in divided doses; maximum of 6.5 mg\/kg\/dayProphylaxis of malaria: 400 mg weekly

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :434<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :30\u201340<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 3<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :Large<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :5.9\u2013504\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>30\u201350 Maximum 75% of dose10\u201330 25\u201350% of dose (equivalent of 150 mg daily)
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 25\u2013 50% of dose (equivalent of 50\u2013100 mg daily) \u2013 use with caution

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR=10\u201330 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anti-arrhythmics: increased risk of ventricular arrhythmias with amiodarone \u2013 avoid concomitant use\n
  • Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin \u2013 avoid concomitant use\n
  • Anti-epileptics: antagonism of anticonvulsant effect\n
  • Antimalarials: increased risk of convulsions with mefloquine; avoid concomitant use with artemether\/lumefantrine\n
  • Ciclosporin: increased ciclosporin concentration (increased risk of toxicity)Digoxin: possibly increased concentration of digoxinLanthanum: absorption possibly reduced by lanthanum \u2013 give at least 2 hours apart

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Take with a meal or a glass of milk Excretory patterns are not well characterised, but hydroxychloroquine and its metabolites are slowly excreted via the kidneysAttempt to avoid prolonged use in renal failureIn renal insufficiency, need more than annual eye examinationsDoses from Seyffart, probably not actually practical to give reduced dose so try giving longer dose intervals
    \n","protected":false},"excerpt":{"rendered":"

    hydroxychloroquine sulphate CLINICAL USE Rheumatoid arthritis Systemic lupus erythematosus Dermatological<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4518","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4518","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4518"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4518\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4518"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4518"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4518"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}