{"id":4515,"date":"2025-03-31T18:12:11","date_gmt":"2025-03-31T18:12:11","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/hydrocortisone-sodium-succinate-txt\/"},"modified":"2025-03-31T18:12:11","modified_gmt":"2025-03-31T18:12:11","slug":"hydrocortisone-sodium-succinate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/hydrocortisone-sodium-succinate-txt\/","title":{"rendered":"hydrocortisone sodium succinate.txt"},"content":{"rendered":"

hydrocortisone sodium succinate <\/h1>\n

CLINICAL USE <\/H3>
\nCorticosteroid:Anti-inflammatory agent in respiratory, GI, endocrine disorders, and allergic statesShock

DOSE IN NORMAL RENAL FUNCTION <\/H3>Oral: 20\u201330 mg in divided doses for replacementIV\/IM: 100\u2013500 mg, 3\u20134 times in 24 hours, or as required

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :484.5 (486.4 as sodium phosphate)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :>90<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : Minimal<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.4\u20130.7<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :Approx 100 minutes\/ Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Antibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycin\n
  • Anticoagulants: efficacy of coumarins may be altered\n
  • Anti-epileptics: metabolism accelerated by carbamazepine, barbiturates, phenytoin and primidone\n
  • Antifungals: increased risk of hypokalaemia with amphotericin \u2013 avoid concomitant use; metabolism possibly inhibited by itraconazole and ketoconazole\n
  • Antivirals: concentration possibly increased by ritonavir\n
  • Ciclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroidsCytotoxics: increased risk of haematological toxicity with methotrexate\n
  • Diuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diureticsVaccines: high dose corticosteroids can impair immune response to vaccines \u2013 avoid concomitant use with live vaccines

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>IV injection, IM injection: add 2 mL of sterile water for injection

    IV infusion <\/H4>: add not more than 2 mL water for injection, then add to 100\u20131000 mL (not less than 100 mL) glucose 5% or sodium chloride 0.9%

    Route <\/H4>IV injection,

    IV infusion <\/H4>, IM

    Rate of Administration <\/H4>IV bolus: 2\u20133 minutes

    Comments<\/H4>Minimum volume 100 mg in 50 mL. (UK Critical Care Group, Minimum Infusion Volumes for fluid restricted critically ill patients, 3rd Edition, 2006)

    OTHER INFORMATION <\/H4>Non-plasma protein bound hydrocortisone is removed by\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :One study has shown that plasma clearance rates of hydrocortisone during haemodialysis were 30\u201363% higher than after dialysis. No recommendations exist to indicate dosing should be altered to take account of this
    \n","protected":false},"excerpt":{"rendered":"

    hydrocortisone sodium succinate CLINICAL USE Corticosteroid:Anti-inflammatory agent in respiratory, GI,<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4515","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4515","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4515"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4515\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4515"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4515"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4515"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}