{"id":4501,"date":"2025-03-31T18:12:10","date_gmt":"2025-03-31T18:12:10","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/dopexamine-hydrochloride-txt\/"},"modified":"2025-03-31T18:12:10","modified_gmt":"2025-03-31T18:12:10","slug":"dopexamine-hydrochloride-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/dopexamine-hydrochloride-txt\/","title":{"rendered":"dopexamine hydrochloride.txt"},"content":{"rendered":"

dopexamine hydrochloride<\/h1>\n

CLINICAL USE <\/H3>
\nInotropic support in exacerbations of heart failure and heart failure associated with cardiac surgery

DOSE IN NORMAL RENAL FUNCTION <\/H3>

IV infusion <\/H4>: 0.5 \u20131 mcg\/kg\/minute and then in increments (0.5\u20131 micrograms\/kg\/minute) up to 6 micrograms\/kg\/minute at not less than 15 minute intervals

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :429.4<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :No data<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 10<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.45<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :6\u201311 minutes\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function and adjust to response
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function and adjust to response
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function and adjust to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide\n
  • Beta-blockers: risk of severe hypertension\n
  • Sympathomimetics: effects of adrenaline and noradrenaline possibly enhanced

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>By intravenous infusion into a central or large peripheral vein

    Rate of Administration <\/H4>See dosage instructions

    Comments<\/H4>

    IV infusion <\/H4> of 400 or 800 micrograms\/mL in glucose 5% or sodium chloride 0.9%Peripheral administration: concentration of infusion solution must not exceed 1 mg\/mL\n
  • Central administration: concentration not >4 mg\/mLRate of administration and duration of therapy should be adjusted according to the patient\u2019s response as determined by heart rate and rhythm, blood pressure, urine flow and measurement of cardiac output

    OTHER INFORMATION <\/H4>Avoid abrupt withdrawal
    \n","protected":false},"excerpt":{"rendered":"

    dopexamine hydrochloride CLINICAL USE Inotropic support in exacerbations of heart<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4501","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4501","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4501"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4501\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4501"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4501"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4501"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}