{"id":4497,"date":"2025-03-31T18:12:10","date_gmt":"2025-03-31T18:12:10","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/docetaxel-txt\/"},"modified":"2025-03-31T18:12:10","modified_gmt":"2025-03-31T18:12:10","slug":"docetaxel-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/docetaxel-txt\/","title":{"rendered":"docetaxel.txt"},"content":{"rendered":"

docetaxel <\/h1>\n

CLINICAL USE <\/H3>
\nAntineoplastic agent:Treatment of breast cancer, prostate cancer and non-small cell lung cancer unresponsive to alternative therapies

DOSE IN NORMAL RENAL FUNCTION <\/H3>Breast cancer: 100 mg\/m 2 every 3 weeksIn combination for breast cancer, non- small cell lung cancer, prostate cancer: 75 mg\/m2 every 3 weeks

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :807.9<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :>95<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 6<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :113 litres<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :4 min(\u03b1)\/36 min(\u03b2)\/11.1 hr(\u03b3)

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAntipsychotics: avoid concomitant use with clozapine \u2013 increased risk of agranulocytosisCiclosporin: possibly inhibits metabolism of ciclosporin

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>With diluent provided

    Route <\/H4>IV

    Rate of Administration <\/H4>Over 1 hour

    Comments<\/H4>Allow vials to come to room temperature for 5 minutesDoses of up to 200 mg can be added to 250 mL infusion bags of glucose 5% or sodium chloride 0.9%Doses greater than 200 mg should be diluted to a concentration of 0.74 mg\/mLAdminister within 4 hours of dilution

    OTHER INFORMATION <\/H4>Give premedication with oral dexamethasone 16 mg daily for 3 days, starting 1 day before commencing chemotherapyCytochrome P\u2013450 mediated metabolism. In animal studies, drug distributed to all tissues and organs except the brain. 6% and 75% of the dose is excreted via the renal and faecal route respectively within 7 days
    \n","protected":false},"excerpt":{"rendered":"

    docetaxel CLINICAL USE Antineoplastic agent:Treatment of breast cancer, prostate cancer<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4497","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4497","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4497"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4497\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4497"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4497"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4497"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}