{"id":4493,"date":"2025-03-31T18:12:10","date_gmt":"2025-03-31T18:12:10","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/disodium-pamidronate-txt\/"},"modified":"2025-03-31T18:12:10","modified_gmt":"2025-03-31T18:12:10","slug":"disodium-pamidronate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/disodium-pamidronate-txt\/","title":{"rendered":"disodium pamidronate .txt"},"content":{"rendered":"

disodium pamidronate <\/h1>\n

CLINICAL USE <\/H3>
\nBisphosphonate:Hypercalcaemia Bone pain Paget\u2019s disease

DOSE IN NORMAL RENAL FUNCTION <\/H3>Hypercalcaemia: depends on serum calcium \u2013 15\u201390 mg in single or divided dosesBone pain: 90 mg every 4 weeks Paget\u2019s disease: 30 mg weekly for 6 weeks, or 30 mg first dose then 60 mg every other week

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :369.1<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :54<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 20\u201355<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.5\u20130.6<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :0.8\u201327\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • 4.0, give 60 mg. Serum calcium <4.0, give 30 mg

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>15 mg in 5 mL water for injection 30 or 90 mg in 10 mL water for injection Final concentration should not exceed 30 mg per 125 mL sodium chloride 0.9%

    Route <\/H4>IV

    Rate of Administration <\/H4>Maximum 20 mg\/hour in patients with impaired renal function

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Rate of acute renal failure is 9.3%, can cause focal segmental glomerulosclerosis, especially at higher doses. (Markowitz GS, Appel GB, Fine PL, et al. Collapsing focal segmental glomerulosclerosis following treatment with high-dose pamidronate. J Am Soc Nephrol. 2001; 12(6): 1164\u201372.)If pamidronate is not excreted adequately, kidney stones may be formedIn dialysis patients there is increased risk of asymptomatic hypocalcaemia with 90 mg doses
    \n","protected":false},"excerpt":{"rendered":"

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