{"id":4492,"date":"2025-03-31T18:12:10","date_gmt":"2025-03-31T18:12:10","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/disodium-etidronate-txt\/"},"modified":"2025-03-31T18:12:10","modified_gmt":"2025-03-31T18:12:10","slug":"disodium-etidronate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/disodium-etidronate-txt\/","title":{"rendered":"disodium etidronate .txt"},"content":{"rendered":"

disodium etidronate <\/h1>\n

CLINICAL USE <\/H3>
\nBisphosphonate:Paget\u2019s disease of bone Vertebral osteoporosis (Didronel PMO)

DOSE IN NORMAL RENAL FUNCTION <\/H3>Paget\u2019s disease: 5\u201320 mg\/kg daily for 3\u20136 monthsVertebral osteoporosis: 400 mg daily for 14 days followed by 76 days of calcium carbonate 1.25 g (= 500 mg calcium)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :250<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Depends on calcium concentration and pH<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 50<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.3\u20131.3<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1\u20136\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Maximum dose = 5 mg\/kg\/day
  • 10 to 20 &nbsp &nbsp : Maximum dose = 5 mg\/kg\/day \u2013 use with caution. (May also use Didronel PMO for osteoporosis.)
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Maximum dose = 5 mg\/kg\/day \u2013 use with caution. (May also use Didronel PMO for osteoporosis)

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsDo not give iron and mineral supplements, antacids or phosphate binders within 2 hours of an etidronate

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Take on an empty stomach. Recommended that patients take with water at the midpoint of a 4 hour fast (i.e. 2 hours before and 2 hours after food)Oral bioavailability is very low; only about 4% of dose is absorbed

    OTHER INFORMATION <\/H4>Renal clearance of etidronate is 1.2 mL\/ minute\/kg, whilst the total body clearance is 2.2 mL\/minute\/kgElimination is likely to be reduced in patients with renal impairment and elderly with reduced renal function necessitating caution. Uptake of etidronate by bone represents non-renal clearance
    \n","protected":false},"excerpt":{"rendered":"

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