{"id":4490,"date":"2025-03-31T18:12:10","date_gmt":"2025-03-31T18:12:10","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/dipyridamole-txt\/"},"modified":"2025-03-31T18:12:10","modified_gmt":"2025-03-31T18:12:10","slug":"dipyridamole-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/dipyridamole-txt\/","title":{"rendered":"dipyridamole.txt"},"content":{"rendered":"

dipyridamole<\/h1>\n

CLINICAL USE <\/H3>
\nCalcium-channel blocker:Prophylaxis and treatment of angina Hypertension

DOSE IN NORMAL RENAL FUNCTION <\/H3>180\u2013500 mg in up to 3 divided doses

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :451<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :80\u201385<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 5<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :3\u20138<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2\u201311; SR: 5\u20138\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Not dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAnaesthetics: enhanced hypotensive effect Anti-arrhythmics: increased risk of bradycardia, AV block and myocardial depression with amiodaroneAntibacterials: metabolism increased by rifampicinAnti-epileptics: effect probably reduced by barbiturates, phenytoin, and primidone; enhanced effect of carbamazepine; increased levels of phenytoinAntihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect of post-synaptic alpha-blockersAntivirals: concentration increased by amprenavir, atazanavir and ritonavir \u2013 reduce dose of diltiazem with atazanavir; concentration reduced by efavirenzBeta-blockers: risk of bradycardia and AV block if co-prescribed with beta-blockersCardiac glycosides: increased digoxin concentrationCiclosporin: increased ciclosporin concentrationsCilostazol: increased cilostazol concentration \u2013 avoid concomitant useIvabradine: avoid concomitant use Sirolimus: sirolimus concentration increasedStatins: increased myopathy with simvastatin. Do not exceed 40 mg of simvastatin with diltiazem.1Tacrolimus: increased tacrolimus concentrationTheophylline: enhanced effect of theophylline

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Active metabolites Monitor heart rate early on in therapy. If falls below 50 beats\/minute, do not increase dose Maintain patient on same brand
    \n","protected":false},"excerpt":{"rendered":"

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