{"id":4488,"date":"2025-03-31T18:12:10","date_gmt":"2025-03-31T18:12:10","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/diazoxide-txt\/"},"modified":"2025-03-31T18:12:10","modified_gmt":"2025-03-31T18:12:10","slug":"diazoxide-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/diazoxide-txt\/","title":{"rendered":"diazoxide.txt"},"content":{"rendered":"

diazoxide<\/h1>\n

CLINICAL USE <\/H3>
\nTreatment of hypertensive emergencies including severe hypertension associated with renal diseaseHypoglycaemia

DOSE IN NORMAL RENAL FUNCTION <\/H3>Hypertension: IV: 1\u20133 mg\/kg; maximum single dose: 150 mg, repeat after 5\u201315 minutesHypoglycaemia: Oral: 3\u20135 mg\/kg in 2\u20133 divided doses; adjust according to response, usually 3\u20138 mg\/kg; total doses up to 1 g have been used

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :230.7<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :>90<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 50<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.2\u20130.3<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :20-45\/30\u201360

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Start with a lower dose and increase gradually according to response. Use with caution

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAntihypertensives and vasodilators: enhanced hypotensive effectMAOIs: withdraw at least 14 days before starting diazoxidePhenytoin: may reduce phenytoin levels

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IV bolus, oral

    Rate of Administration <\/H4><30 seconds

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Single doses above 300 mg have been associated with angina and myocardial and cerebral infarction. Can cause sodium and water retention
    \n","protected":false},"excerpt":{"rendered":"

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