{"id":4465,"date":"2025-03-31T18:12:09","date_gmt":"2025-03-31T18:12:09","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/venlafaxine-txt\/"},"modified":"2025-03-31T18:12:09","modified_gmt":"2025-03-31T18:12:09","slug":"venlafaxine-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/venlafaxine-txt\/","title":{"rendered":"Venlafaxine.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Antidepressant: Depressive illness Generalised anxiety disorders

DOSE IN NORMAL RENAL FUNCTION <\/H3> 37.5\u2013187.5 mg twice daily XL: 75\u2013225 mg daily Generalised anxiety disorder: 75 mg once daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 277; (313.9 as hydrochloride) <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 27 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 5 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 7.5 <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 5\/6\u20138 XL: 9\u201321

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4> 30\u201350 Dose as in normal renal function 10\u201330 Reduce total dose by 50% and administer daily
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Reduce total dose by 50% and administer daily

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Not dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Not dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp : Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp: Not dialysed. Dose as in GFR=10\u201330 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs\n
  • Analgesics: increased risk of bleeding with aspirin and NSAIDs\n
  • Anticoagulants: effects of warfarin possibly enhanced\n
  • Antidepressants: avoid concomitant use with MAOIs and moclobemide (increased risk of toxicity); possibly enhanced serotonergic effects with duloxetine\n
  • Antimalarials: avoid concomitant use with artemether\/lumefantrine\n
  • Antipsychotics: increases concentration of clozapine and haloperidol\n
  • Dopaminergics: use entacapone with caution; increased risk of hypertension and CNS excitation with selegiline \u2013 avoid concomitant use\n
  • Sibutramine: increased risk of CNS toxicity \u2013 avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> Oral

    Rate of Administration <\/H4> \u2013

    Comments<\/H4> \u2013

    OTHER INFORMATION <\/H4> Withhold dose until after haemodialysis to minimise nausea and any other side effects May be used to treat peripheral diabetic neuropathy in haemodialysis patients; dose is up to 75 mg daily. www.medscape.com\/ viewarticle\/440202 An ECG is required before treatment .
    \n","protected":false},"excerpt":{"rendered":"

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