{"id":4464,"date":"2025-03-31T18:12:09","date_gmt":"2025-03-31T18:12:09","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/varenicline-txt\/"},"modified":"2025-03-31T18:12:09","modified_gmt":"2025-03-31T18:12:09","slug":"varenicline-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/varenicline-txt\/","title":{"rendered":"Varenicline.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Aid to smoking cessation

DOSE IN NORMAL RENAL FUNCTION <\/H3> 0.5 mg once daily for 3 days, 0.5 mg twice daily for 3 days, then 0.5\u20131 mg twice daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 361.3 (as tartrate) <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : <20 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 92 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 415 litres <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 24\/Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4> Initial doses as for normal renal function, then maintenance doses of: 30\u201350 1 mg once or twice daily 10\u201330 1 mg once daily
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 0.5\u20131 mg once daily

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp : Dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp: Dialysed. Dose as in GFR=10\u201330 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs\n
  • None known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> Oral

    Rate of Administration <\/H4> \u2013

    Comments<\/H4> \u2013 .
    \n","protected":false},"excerpt":{"rendered":"

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