{"id":4463,"date":"2025-03-31T18:12:09","date_gmt":"2025-03-31T18:12:09","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/vardenafil-txt\/"},"modified":"2025-03-31T18:12:09","modified_gmt":"2025-03-31T18:12:09","slug":"vardenafil-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/vardenafil-txt\/","title":{"rendered":"Vardenafil.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Treatment of erectile dysfunction

DOSE IN NORMAL RENAL FUNCTION <\/H3> 5\u201320 mg approximately 25\u201360 minutes before sexual activity

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 488.6 <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 95 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 2\u20136 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 208 litres <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 4\u20135

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4> Initial doses as for normal renal function, then maintenance doses of: 30\u201350 Dose as in normal renal function 10\u201330 Initial dose 5 mg and adjust accordingly
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Initial dose 5 mg and adjust accordingly

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Not dialysed. Dose as in GFR <10 mL\/min. Use with caution <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Not dialysed. Dose as in GFR <10 mL\/min. Use with caution
  • HDF\/high flux &nbsp : Unknown dialysability. Dose as in GFR <10 mL\/min. Use with caution
  • CAV\/VVHD &nbsp &nbsp &nbsp: Not dialysed. Dose as in GFR=10\u201330 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs Alpha-blockers: enhanced hypotensive effect \u2013 avoid for 6 hours after alpha- blockers (max dose 5 mg)\n
  • Antifungals: concentration increased by ketoconazole, and itraconazole \u2013 avoid concomitant use\n
  • Antivirals: concentration increased by amprenavir, indinavir, ritonavir, saquinavir \u2013 avoid with indinavir and ritonavir; reduce initial dose with saquinavir\n
  • Grapefruit juice: concentration possibly increased \u2013 avoid concomitant use Nicorandil: possibly enhanced hypotensive effect \u2013 avoid concomitant use\n
  • Nitrates: possibly enhanced hypotensive effect \u2013 avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> Oral

    Rate of Administration <\/H4> \u2013

    Comments<\/H4> \u2013

    OTHER INFORMATION <\/H4>\n
  • Contraindicated in dialysis patients due to lack of information, therefore suggest use with caution and monitor patients closely .
    \n","protected":false},"excerpt":{"rendered":"

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