{"id":4437,"date":"2025-03-31T18:12:08","date_gmt":"2025-03-31T18:12:08","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tropisetron-txt\/"},"modified":"2025-03-31T18:12:08","modified_gmt":"2025-03-31T18:12:08","slug":"tropisetron-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tropisetron-txt\/","title":{"rendered":"Tropisetron.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Anti-emetic: Cancer chemotherapy Postoperative nausea and vomiting (PONV)

DOSE IN NORMAL RENAL FUNCTION <\/H3> Chemotherapy: IV bolus or infusion of 5 mg before chemotherapy, then 5 mg every morning orally for 5 days PONV: IV bolus or infusion of 2 mg before induction of anaesthesia, then 2 mg within 2 hours of the end of surgery

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 284.4 (320.8 as hydrochloride) <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 71 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 8 (70% as metabolites) <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 400\u2013600 litres <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 8\u201345 (depends on metaboliser status)\/ Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unlikely to be dialysed. Dose as in normal renal function <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Unlikely to be dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp : Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs\n
  • Anti-arrhythmics: increased risk of ventricular arrhythmias \u2013 use with caution; avoid with amiodarone, disopyramide, flecainide, lidocaine, mexiletine, procainamide or propafenone\n
  • Beta-blockers: increased risk of ventricular arrhythmias \u2013 use with caution; avoid with sotalol

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> Oral, IV bolus,

    IV infusion <\/H4>

    Rate of Administration <\/H4> Bolus: over at least 1 minute Infusion: over 15 minutes

    Comments<\/H4> Can be added to 100 mL sodium chloride 0.9%, glucose 5% or Ringer\u2019s solution Give oral preparation at least an hour before food

    OTHER INFORMATION <\/H4> In impaired kidney function, plasma concentrations of tropisetron may be increased by up to 50%, but no problem with short courses .
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Anti-emetic: Cancer chemotherapy Postoperative nausea and vomiting (PONV)<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4437","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4437","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4437"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4437\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4437"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4437"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4437"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}