{"id":4432,"date":"2025-03-31T18:12:08","date_gmt":"2025-03-31T18:12:08","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/triamterene-txt\/"},"modified":"2025-03-31T18:12:08","modified_gmt":"2025-03-31T18:12:08","slug":"triamterene-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/triamterene-txt\/","title":{"rendered":"Triamterene.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Diuretic (potassium-sparing)

DOSE IN NORMAL RENAL FUNCTION <\/H3> 150\u2013250 mg daily in divided doses; reduce to alternate days after 1 week

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 253 <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 60 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 5\u201310 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 2.2\u20133.7 <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 2\/10

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Avoid. See \u2018Other Information\u2019
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Avoid. See \u2018Other Information\u2019

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability. Avoid <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Unknown dialysability. Avoid
  • HDF\/high flux &nbsp : Unknown dialysability. Avoid
  • CAV\/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Avoid

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs ACE inhibitors and angiotensin-II antagonists: enhanced hypotensive effect (risk of severe hyperkalaemia)\n
  • Analgesics: increased risk of nephrotoxicity with NSAIDs; increased risk of hyperkalaemia, especially with indometacin; antagonism of hypotensive effect\n
  • Antibacterials: avoid concomitant use with lymecycline\n
  • Antidepressants: enhanced hypotensive effect with MAOIs; increased risk of postural hypotension with tricyclics\n
  • Antipsychotics: enhanced hypotensive effect with phenothiazines Antihypertensives: enhanced hypotensive effect; increased risk of first dose hypotensive effect of post-synaptic alpha- blockers, e.g. prazosin\n
  • Ciclosporin: increased risk of hyperkalaemia\n
  • Lithium: reduced excretion of lithium (risk of lithium toxicity)\n
  • Potassium salts: increased risk of hyperkalaemia\n
  • Tacrolimus: increased risk of hyperkalaemia

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> Oral

    Rate of Administration <\/H4> \u2013

    Comments<\/H4> \u2013

    OTHER INFORMATION <\/H4> Hyperkalaemia is common when GFR<30 mL\/min. May cause acute renal failure Potassium-sparing diuretics are weak diuretics and are ineffective in moderate to severe renal failure .
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Diuretic (potassium-sparing) DOSE IN NORMAL RENAL FUNCTION 150\u2013250<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4432","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4432","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4432"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4432\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}