{"id":4428,"date":"2025-03-31T18:12:08","date_gmt":"2025-03-31T18:12:08","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tranexamic-acid-txt\/"},"modified":"2025-03-31T18:12:08","modified_gmt":"2025-03-31T18:12:08","slug":"tranexamic-acid-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tranexamic-acid-txt\/","title":{"rendered":"Tranexamic acid.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Haemostatic agent

DOSE IN NORMAL RENAL FUNCTION <\/H3> Oral: 1\u20131.5 g every 8\u201312 hours (15\u201325 mg\/ kg every 8\u201312 hours) IV: 0.5\u20131 g every 8 hours (25\u201350 mg\/kg daily in divided doses) Dose depends on indication

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 157.2 <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 3 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 90 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 1 <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 2\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : IV: 10 mg\/kg 12 hourly. Oral: 25 mg\/ kg 12 hourly
  • 10 to 20 &nbsp &nbsp : IV: 10 mg\/kg 12\u201324 hourly. Oral: 25 mg\/kg 12\u201324 hourly
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : IV: 5 mg\/kg 12\u201324 hourly. Oral: 12.5 mg\/kg 12\u201324 hourly

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Unknown dialysability. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp : Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs\n
  • None known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> IV, oral

    Rate of Administration <\/H4> Slow bolus =100 mg\/minute or continuous

    IV infusion <\/H4> in glucose 5% or sodium chloride 0.9%

    Comments<\/H4> \u2013

    OTHER INFORMATION <\/H4> A 5% topical solution can be made up using the IV preparation, mixed with water for injection. This can be used as a mouthwash to stop bleeding after dental surgery, or placed on a swab to reduce bleeding at fistula or other bleeding sites if conventional measures have not worked (anecdotal) .
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Haemostatic agent DOSE IN NORMAL RENAL FUNCTION Oral:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4428","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4428"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4428\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}