{"id":4420,"date":"2025-03-31T18:12:07","date_gmt":"2025-03-31T18:12:07","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tobramycin-txt\/"},"modified":"2025-03-31T18:12:07","modified_gmt":"2025-03-31T18:12:07","slug":"tobramycin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tobramycin-txt\/","title":{"rendered":"Tobramycin.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Antibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3> IM\/IV: 3 mg\/kg\/day in 3 divided doses; maximum 5 mg\/kg\/day in 3\u20134 divided doses Urinary tract infections: 2\u20133 mg\/kg daily as a single dose (IM)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 467.5 <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : <5 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 90 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 0.25 <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 2\u20133\/5\u201370

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Give 1\u20132 mg\/kg then dose according to serum levels
  • 10 to 20 &nbsp &nbsp : Give 1 mg\/kg then dose according to serum levels
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Give 1 mg\/kg then dose according to serum levels

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp : Dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp: Dialysed. 1.5\u20132 mg\/kg every 24 hours and monitor levels1

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs Botulinum toxin: neuromuscular block enhanced \u2013 risk of toxicity\n
  • Ciclosporin: increased risk of nephrotoxicity Cytotoxics: increased risk of nephrotoxicity and possibly of ototoxicity with platinum compounds\n
  • Diuretics: increased risk of ototoxicity with loop diuretics Muscle relaxants: enhanced effect of non-depolarising muscle relaxants and suxamethonium Parasympathomimetics: antagonism of effect of neostigmine and pyridostigmine\n
  • Tacrolimus: increased risk of nephrotoxicity

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> Add to 50\u2013100 mL sodium chloride 0.9% or glucose 5% for

    IV infusion <\/H4>

    Route <\/H4> IV, IM, IP, nebulised

    Rate of Administration <\/H4> 20\u201360 minutes

    Comments<\/H4> Plasma concentrations should be measured frequently; trough \u22642 mg\/L, peak 60 minutes post dose \u226410 mg\/L; avoid prolonged peaks above 12 mg\/L

    OTHER INFORMATION <\/H4> 25\u201370% can be removed by haemodialysis Used via nebuliser for chronic pulmonary Pseudomonas aeruginosa infection in cystic fibrosis: 300 mg every 12 hours for 28 days, repeat after 28 days Can be used for peritonitis at doses of 6 mg\/L intraperitoneally
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION IM\/IV:<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4420","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4420"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4420\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}