{"id":4419,"date":"2025-03-31T18:12:07","date_gmt":"2025-03-31T18:12:07","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tizanidine-txt\/"},"modified":"2025-03-31T18:12:07","modified_gmt":"2025-03-31T18:12:07","slug":"tizanidine-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tizanidine-txt\/","title":{"rendered":"Tizanidine.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Spasticity associated with multiple sclerosis or spinal cord injury\/disease

DOSE IN NORMAL RENAL FUNCTION <\/H3> 2\u201324 mg daily in up to 3\u20134 divided doses (depending on response)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 290.2 (as hydrochloride) <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 30 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <11 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : 2.4 <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : 2\u20134\/Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4> 25\u201350 Dose as in normal renal function <25 Initial dose 2 mg once daily and slowly increase by 2 mg increments. Increase daily dose before increasing frequency of administration

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR<25 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Unknown dialysability. Dose as in GFR<25 mL\/min
  • HDF\/high flux &nbsp : Unknown dialysability. Dose as in GFR<25 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp: Unknown dialysability. Dose as in GFR=25\u201350 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs\n
  • Anti-arrhythmics: enhanced muscle relaxant effect with procainamide\n
  • Antibacterials: concentration increased by ciprofloxacin \u2013 avoid concomitant use Antihypertensives: enhanced hypotensive effect Oral contraceptives: clearance of tizanidine reduced by 50%

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> Oral

    Rate of Administration <\/H4> \u2013

    Comments<\/H4> \u2013

    OTHER INFORMATION <\/H4> Pharmacokinetic data suggest that renal clearance in the elderly may be decreased by up to 3-fold May induce hypotension; therefore may potentiate the effect of antihypertensive drugs, including diuretics \u2013 exercise caution With beta-blockers or digoxin, may potentiate hypotension or bradycardia LFTs should be monitored monthly for the first 4 months Tizanidine undergoes rapid and extensive first pass metabolism. The metabolites (mainly inactive) constitute 70% of the administered dose and are excreted via the renal route
    \n","protected":false},"excerpt":{"rendered":"

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