{"id":4412,"date":"2025-03-31T18:12:07","date_gmt":"2025-03-31T18:12:07","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/tiludronic-acid-txt\/"},"modified":"2025-03-31T18:12:07","modified_gmt":"2025-03-31T18:12:07","slug":"tiludronic-acid-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/tiludronic-acid-txt\/","title":{"rendered":"Tiludronic acid.txt"},"content":{"rendered":"

CLINICAL USE <\/H3> Paget\u2019s disease of bone

DOSE IN NORMAL RENAL FUNCTION <\/H3> 400 mg daily for 12 weeks

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 318.6 <\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : 91 <\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 60 <\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp : No data <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp : >100\/205

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4> 60\u201390 Use with caution 30\u201360 Use with caution <30 Avoid

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: Unlikely to be dialysed. Avoid <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : Unlikely to be dialysed. Avoid
  • HDF\/high flux &nbsp : Unknown dialysability. Avoid
  • CAV\/VVHD &nbsp &nbsp &nbsp: Unlikely to be dialysed. Avoid

    IMPORTANT DRUG INTERACTIONS <\/H3> Potentially hazardous interactions with other drugs Calcium salts: reduced absorption

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4> Oral

    Rate of Administration <\/H4> \u2013

    Comments<\/H4> \u2013

    OTHER INFORMATION <\/H4> Take as a single dose with a glass of water at least 2 hours before or after meals, calcium supplements or aluminium or magnesium containing antacids Patients should ensure their calcium and vitamin D intake is adequate Calcium metabolism disorders should be corrected before starting therapy Bisphosphonates are mainly eliminated by excretion of unchanged drug in the urine .
    \n","protected":false},"excerpt":{"rendered":"

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