{"id":4399,"date":"2025-03-31T18:12:06","date_gmt":"2025-03-31T18:12:06","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/temocillin-txt\/"},"modified":"2025-03-31T18:12:06","modified_gmt":"2025-03-31T18:12:06","slug":"temocillin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/temocillin-txt\/","title":{"rendered":"Temocillin.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>1\u20132 g every 12 hoursAcute uncomplicated UTIs: 1 g daily in a single or divided doses

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :458.4 (as sodium salt)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :75\u201385<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 90<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.23<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3.1\u20135.4\/28.2

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>30\u201350 Dose as in normal renal function 10\u201330 1\u20132 g daily
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 1\u20132 g every 48 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR=10\u201330 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsTemocillin can reduce the excretion of methotrexate (increased risk of toxicity)

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>IV: Dissolve in 20 mL water for injection

    IV infusion <\/H4>: Dilute in 50\u2013100 mL sodium chloride 0.9%IM: Dissolve in 2 mL water for injection or lidocaine 0.5\u20131% (volume 2.7 mL)

    Route <\/H4>IV, IM

    Rate of Administration <\/H4>Slow IV bolus over 3\u20134 minutes Infusion over 30\u201340 minutes

    Comments<\/H4>Incompatible with proteins, blood products, lipid emulsions and aminoglycosides

    OTHER INFORMATION <\/H4>Bleeding has occurred in some patients (more likely in those with renal impairment)20% is removed by haemodialysis and 17\u201326% by peritoneal dialysis.
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION 1\u20132<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4399","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4399","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4399"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4399\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}