{"id":4367,"date":"2025-03-31T18:12:05","date_gmt":"2025-03-31T18:12:05","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/streptokinase-txt\/"},"modified":"2025-03-31T18:12:05","modified_gmt":"2025-03-31T18:12:05","slug":"streptokinase-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/streptokinase-txt\/","title":{"rendered":"Streptokinase.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nFibrinolytic:Thrombolysis in DVT, PE, acute arterial thromboembolism, acute MI, thrombosed A-V shunts

DOSE IN NORMAL RENAL FUNCTION <\/H3>Loading dose: 250 000 IU followed by 100 000 IU\/hour for 12\u201372 hours (refer to SPC)Myocardial Infarction: 1.5 MIU followed by aspirinThrombosed <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : shunts: 10\u201325 000 IU sealed in shunt and repeated after 30\u201345 minutes

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :47 408<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :No data<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 0<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.02\u20130.08<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :18 minutes\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAnticoagulants should not be given with streptokinaseHeparin infusions should be stopped 4 hours before streptokinase infusion. If this is not possible, protamine sulphate should be used to neutralise the heparin; heparin infusions can be restarted 4 hours post streptokinase infusion followed by oral anticoagulants

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>See manufacturer\u2019s literature

    Route <\/H4>IV

    Rate of Administration <\/H4>Give loading dose of 250 000 IU in 100 mL fluid over 30 minutes, followed by an appropriate volume for the maintenance doseGive 1.5 MIU for acute MI in 50\u2013200 mL fluid over 1 hour

    Comments<\/H4>For occluded\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : shunts, add 100 000 IU to 100 mL sodium chloride 0.9% and put 10\u201325 mL into the clotted portion of the shunt

    OTHER INFORMATION <\/H4>There are no significant changes in pharmacokinetics in patients with renal insufficiency. Dosage reduction is therefore not necessary.
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Fibrinolytic:Thrombolysis in DVT, PE, acute arterial thromboembolism, acute<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4367","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4367"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4367\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}