{"id":4277,"date":"2025-03-31T18:12:03","date_gmt":"2025-03-31T18:12:03","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/paliperidone-txt\/"},"modified":"2025-03-31T18:12:03","modified_gmt":"2025-03-31T18:12:03","slug":"paliperidone-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/paliperidone-txt\/","title":{"rendered":"Paliperidone.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nAtypical antipsychotic for schizophrenia

DOSE IN NORMAL RENAL FUNCTION <\/H3>3\u201312 mg once daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :426.5<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :74<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 59<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :487 litres<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :23\/51

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>50\u201380 3 mg once daily and increase according to response30\u201350 3 mg once daily and increase according to response10\u201330 3 mg alternate days, increasing to 3 mg daily according to response
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 3 mg alternate days, increasing to 3 mg daily according to response. Use with caution

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR=10\u201330 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anaesthetics: enhanced hypotensive effect\n
  • Anti-arrhythmics: increased risk of ventricular arrhythmias when given with anti-arrhythmics that prolong the QT interval\n
  • Antidepressants: increases concentration of tricyclics (possibly increased risk of ventricular arrhythmias)\n
  • Antimalarials: avoidance of antipsychotics advised by manufacturer of artemether\/lumefantrine\n
  • Atomoxetine: increased risk of ventricular arrhythmias with atomoxetine\n
  • Anti-epileptics: antagonise anticonvulsant effect (convulsive threshold lowered)\n
  • Antivirals: concentration possibly increased by ritonavir\n
  • Sibutramine: increased risk of CNS toxicity \u2013 manufacturer of sibutramine advises avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Clearance is reduced by 71% in ERF\n
  • Contraindicated (by manufacturer) in patients with GFR <10 mL\/min, due to lack of experience.
    \n","protected":false},"excerpt":{"rendered":"

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