{"id":4212,"date":"2025-03-31T18:12:01","date_gmt":"2025-03-31T18:12:01","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/mycophenolate-txt\/"},"modified":"2025-03-31T18:12:01","modified_gmt":"2025-03-31T18:12:01","slug":"mycophenolate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/mycophenolate-txt\/","title":{"rendered":"Mycophenolate.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nMycophenolate sodium: for renal transplantationMycophenolate mofetil: prophylaxis against acute transplant rejection; autoimmune renal diseases

DOSE IN NORMAL RENAL FUNCTION <\/H3>Mycophenolate sodium: 720 mg twice dailyMycophenolate mofetil: 1\u20131.5 g twice a day

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :320.3 (mycophenolic acid) 433.5 (as mofetil) 342.3 (as sodium)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :97<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <1<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :3.6\u20134 <\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :12\u201317.9\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Mycophenolate mofetil: 1 g twice a day; mycophenolate sodium: dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Mycophenolate mofetil: 1 g twice a day; mycophenolate sodium: dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Antipsychotics: avoid concomitant use with clozapine (increased risk of agranulocytosis)\n
  • Antivirals: higher concentrations of both mycophenolate acid and aciclovir or ganciclovir when the two are prescribed concomitantlyAntacids: absorption of mycophenolate decreased in presence of magnesium and aluminium saltsColestyramine: 40% reduction in oral bioavailability of mycophenolate\n
  • Ciclosporin: some studies show that ciclosporin decreases plasma MPA AUC levels; other studies show increases \u2013 no dose change requiredIron preparations: may significantly reduce absorption of mycophenolateSevelamer: reduced levels of mycophenolate\n
  • Tacrolimus: increases MPA concentrations\u2013 no dose change required but monitor closely

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Add 14 mL of glucose 5% per 500 mg vial

    Route <\/H4>Oral, IV

    Rate of Administration <\/H4>Over 2 hours

    Comments<\/H4>Dilute reconstituted solution further with glucose 5% to achieve a concentration of 6 mg\/mL

    OTHER INFORMATION <\/H4>Mycophenolate mofetil (MMF) rapidly undergoes complete presystemic absorption to mycophenolic acid (MPA) which in turn is metabolised to MPA glucuronide. This undergoes extensive enterohepatic recirculation, hence a secondary increase in MPA plasma levels is seen 6\u201312 hours post doseIf neutrophil count drops below 1.3 \u00d7 10 3\/\u03bcL, consider suspending MMF therapyNo dosage reduction is required in the event of a transplant rejection episodeMycophenolate sodium 720 mg is approximately equivalent to 1 g mycophenolate mofetil.
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Mycophenolate sodium: for renal transplantationMycophenolate mofetil: prophylaxis against<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4212","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4212"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4212\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}