{"id":4190,"date":"2025-03-31T18:12:00","date_gmt":"2025-03-31T18:12:00","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/meropenem-txt\/"},"modified":"2025-03-31T18:12:00","modified_gmt":"2025-03-31T18:12:00","slug":"meropenem-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/meropenem-txt\/","title":{"rendered":"Meropenem.txt"},"content":{"rendered":"

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>500 mg \u2013 1 g every 8 hoursHigher doses used in cystic fibrosis and meningitis (up to 2 g every 8 hours)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :437.5<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :2<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 70<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.351<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1\/6\u201313.72

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : 500 mg \u2013 2 g every 12 hours
  • 10 to 20 &nbsp &nbsp : 500 mg \u2013 1 g every 12 hours or 500 mg every 8 hours
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 500 mg \u2013 1 g every 24 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min or 1\u20132 g post dialysis2
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. 0.5\u20131 g every 8 hours2,3 or 1 g every 12 hours1 CVVhdF1 g every 12 hours3

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsProbenecid: avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Add 5 mL water for injection to each 250 mg of meropenem

    Route <\/H4>IV

    Rate of Administration <\/H4>Bolus: 5 minutes IV Infusion: 15\u201330 minutes

    Comments<\/H4>Further dilute in 50\u2013200 mL sodium chloride 0.9%, glucose 5% or glucose 10% if for infusionStable for 24 hours once reconstituted Minimum volume 1 g in 10 mL. (UK Critical Care Group, Minimum Infusion Volumes for fluid restricted critically ill patients, 3 rd Edition, 2006)

    OTHER INFORMATION <\/H4>Metabolite is inactive and renally excreted Each 1 g vial contains 3.9 mmol of sodium Has less potential to induce seizures than imipenemHas been used intraperitoneally for peritoneal dialysis Pseudomonas peritonitis at concentration of 100 mg\/L50% is removed by CVVHF, 13\u201353% by CVVHDF, 50% by intermittent\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :.2Differences in renal replacement doses are due to the different flow rates used in the studies
    \n","protected":false},"excerpt":{"rendered":"

    CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION 500<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4190","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4190","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4190"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4190\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4190"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4190"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4190"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}