{"id":4129,"date":"2025-03-31T18:11:58","date_gmt":"2025-03-31T18:11:58","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/lamivudine-txt\/"},"modified":"2025-03-31T18:11:58","modified_gmt":"2025-03-31T18:11:58","slug":"lamivudine-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/lamivudine-txt\/","title":{"rendered":"Lamivudine.txt"},"content":{"rendered":"

Lamivudine <\/h1>\n

CLINICAL USE <\/H3>
\nNucleoside reverse transcriptase inhibitor:Treatment of HIV in combination with other antiretroviral drugsTreatment of chronic hepatitis B in adults

DOSE IN NORMAL RENAL FUNCTION <\/H3>HIV: 150 mg twice daily or 300 mg dailyHepatitis B: 100 mg daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :229.3<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :<36<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 70<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :1.3<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :5\u20137\/20

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>30\u201350 HIV: 150 mg daily. Hepatitis B: 100 mg stat then 50 mg daily15\u201330 HIV: 150 mg stat then 100 mg daily. Hepatitis B: 100 mg stat then 25 mg daily5\u201315 HIV: 150 mg stat then 50 mg daily. Hepatitis B: 35 mg stat then 15 mg daily<5 HIV: 150 mg stat then 25\u201350 mg daily.1,2 Hepatitis B: 35 mg stat then 10 mg daily

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR<5 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR<5 mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR<5 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR=5\u201315 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsTrimethoprim: inhibits excretion of lamivudine \u2013 avoid concomitant use of high dose co-trimoxazole\n
  • Antivirals: avoid concomitant use with foscarnet, emtricitabine and IV ganciclovir

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Administer with or without food

    OTHER INFORMATION <\/H4>15 mL of oral suspension contains 3 g of sucroseDosage from Bennett (4th edition): GFR>50 mL\/min: 100% of doseGFR=10\u201350 mL\/min: 150 mg loading dose then 50\u2013150 mg dailyGFR <10 mL\/min: 50 mg loading dose then 25\u201350 mg daily
    \n","protected":false},"excerpt":{"rendered":"

    Lamivudine CLINICAL USE Nucleoside reverse transcriptase inhibitor:Treatment of HIV in<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4129","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4129","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4129"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4129\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4129"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4129"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4129"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}