{"id":4102,"date":"2025-03-31T18:11:58","date_gmt":"2025-03-31T18:11:58","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/klean-prep-txt\/"},"modified":"2025-03-31T18:11:58","modified_gmt":"2025-03-31T18:11:58","slug":"klean-prep-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/klean-prep-txt\/","title":{"rendered":"Klean-Prep.txt"},"content":{"rendered":"

Klean-Prep <\/h1>\n

CLINICAL USE <\/H3>
\nColonic lavage prior to diagnostic examination or surgical procedures requiring a clean colon

DOSE IN NORMAL RENAL FUNCTION <\/H3>4 sachets, each reconstituted in 1 litre of water, at a rate of 250 mL every 10\u201315 minutes

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :3350 (Macrogol)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :N\/A<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : N\/A<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :N\/A<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :N\/A

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not absorbed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not absorbed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Not absorbed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not absorbed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • None known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Each sachet in 1 litre of water

    Route <\/H4>Oral

    Rate of Administration <\/H4>250 mL every 15\u201330 minutes If given via NG tube, rate is 20\u201330 mL\/ minute

    Comments<\/H4>Klean-Prep is formulated to be hyper- osmotic and draw water into the bowel. None is absorbed systemically

    OTHER INFORMATION <\/H4>Each sachet of Klean-Prep contains:Polyethylene glycol 3350 \u2013 59.0 g \u2014Anhydrous sodium sulphate \u2013 5.685 g \u2014Sodium bicarbonate \u2013 1.685 g \u2014Sodium chloride \u2013 1.465 g \u2014Potassium chloride \u2013 0.7425 g \u2014The electrolyte content of 1 sachet when made up in 1 litre of water is:Sodium \u2013 125 mmol \u2014Sulphate \u2013 40 mmol \u2014Chloride \u2013 35 mmol \u2014Bicarbonate \u2013 20 mmol \u2014Potassium \u2013 10 mmol
    \n","protected":false},"excerpt":{"rendered":"

    Klean-Prep CLINICAL USE Colonic lavage prior to diagnostic examination or<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4102","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4102"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4102\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4102"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4102"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}