{"id":4088,"date":"2025-03-31T18:11:57","date_gmt":"2025-03-31T18:11:57","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ispaghula-husk-txt\/"},"modified":"2025-03-31T18:11:57","modified_gmt":"2025-03-31T18:11:57","slug":"ispaghula-husk-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ispaghula-husk-txt\/","title":{"rendered":"Ispaghula husk .txt"},"content":{"rendered":"

Ispaghula husk <\/h1>\n

CLINICAL USE <\/H3>
\nBulk-forming laxative

DOSE IN NORMAL RENAL FUNCTION <\/H3>Fibrelief: 1\u20136 sachets daily in water in 1\u20133 divided dosesFybogel: One sachet (3.5 g) in water twice dailyIsogel: 2 teaspoonfuls in water 1\u20132 times daily (constipation), 3 times daily (diarrhoea)Regulan: 1 sachet in water 1\u20133 times daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :\u2013<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :0<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 0<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :Not absorbed<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :Not absorbed

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Not dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • None known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4> \u2013

    Comments<\/H4>Fybogel and regulan should be stirred into 150 mL water and taken as quickly as possible, preferably after mealsAdditional fluid intake should be maintained

    OTHER INFORMATION <\/H4>Fybogel is low in sodium and potassium, containing approximately 0.4 mmol sodium and 0.7 mmol potassium per sachet. It is sugar and gluten free and contains aspartame (contributes to the phenylalanine intake and may affect control of phenylketonuria)Orange and lemon\/lime flavours of regulan contain: 3.4 g ispaghula husk BP, 0.23 mmol sodium, <1 mmol potassium per sachet and are gluten and sugar free. They also contain aspartameFibrelief contains aspartame Fluid restrictions in dialysis patients can render these treatments inappropriate
    \n","protected":false},"excerpt":{"rendered":"

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