{"id":4046,"date":"2025-03-31T18:11:56","date_gmt":"2025-03-31T18:11:56","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/granisetron-txt\/"},"modified":"2025-03-31T18:11:56","modified_gmt":"2025-03-31T18:11:56","slug":"granisetron-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/granisetron-txt\/","title":{"rendered":"Granisetron.txt"},"content":{"rendered":"

Granisetron <\/h1>\n

CLINICAL USE <\/H3>
\nPrevention or treatment of nausea and vomiting induced by cytotoxic chemotherapy, radiotherapy, or postoperative nausea and vomiting (PONV)

DOSE IN NORMAL RENAL FUNCTION <\/H3>Cytotoxic chemotherapy or radiotherapy: PO: 1\u20132 mg within 1 hour before start \u2014of treatment, then 2 mg daily in 1\u20132 divided doses during treatmentIV: 3 mg before start of cytotoxic \u2014therapy; up to 2 additional 3 mg doses can be given within 24 hours no less than 10 minutes apartIV Infusion: 40 mcg\/kg (max 3 mg) \u2014before treatment; repeated once more if requiredPONV: 1 mg IV before induction of anaesthesia; then 1 mg as required (maximum 2 mg in one day)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :312.4 (348.9 as hydrochloride)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :\u224865<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <20<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :3<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :4\u20135\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in normal renal function. Company recommends timing\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : for greater than 2 hours after granisetron dose
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function. Company recommends timing\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp : for greater than 2 hours after granisetron dose
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • None known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral, IV bolus,

    IV infusion <\/H4>

    Rate of Administration <\/H4>IV bolus: diluted in 5 mL sodium chloride 0.9% over not less than 30 seconds

    IV infusion <\/H4>:
  • 20 to 50 &nbsp &nbsp : mL over 5 minutes

    Comments<\/H4>Compatible with sodium chloride 0.9%, sodium chloride 0.18% and glucose 4% solution, glucose 5%, Hartmann\u2019s solution, sodium lactate injection, 10% mannitolMaximum administered dose over 24 hours should not exceed 9 mg

    OTHER INFORMATION <\/H4>No special dosing adjustments necessary in patients with renal or hepatic failure.
    \n","protected":false},"excerpt":{"rendered":"

    Granisetron CLINICAL USE Prevention or treatment of nausea and vomiting<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4046","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4046"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4046\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}