{"id":4045,"date":"2025-03-31T18:11:56","date_gmt":"2025-03-31T18:11:56","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/glyceryl-trinitrate-txt\/"},"modified":"2025-03-31T18:11:56","modified_gmt":"2025-03-31T18:11:56","slug":"glyceryl-trinitrate-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/glyceryl-trinitrate-txt\/","title":{"rendered":"Glyceryl trinitrate.txt"},"content":{"rendered":"

Glyceryl trinitrate <\/h1>\n

CLINICAL USE <\/H3>
\nVasodilator:Treatment and prophylaxis of angina, left ventricular failure, hypertension during surgeryAnal fissures

DOSE IN NORMAL RENAL FUNCTION <\/H3>S\/L tablets: 0.3\u20131 mg as required Buccal: 2\u201310 mg 3 times daily or when requiredOral dose depends on preparation used Patches: 5\u201315 mg every 24 hours

IV infusion <\/H4>: 10\u2013200 mcg\/minute; up to 400 mcg\/min may be required during surgeryAnal fissures: 0.2\u20130.8% ointment every 12 hours

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :227.1<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :30\u201360<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <1<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :2\u20133<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1\u20134 minutes\/unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anticoagulants: infusion of GTN reduces anticoagulant effect of heparins\n
  • Antidepressants: tricyclics may reduce effect of sublingual tablets due to dry mouthAntimuscarinics: may reduce effect of sublingual tablets due to dry mouthSildenafil: hypotensive effect significantly enhanced \u2013 avoid concomitant useTadalafil: hypotensive effect significantly enhanced \u2013 avoid concomitant use\n
  • Vardenafil: hypotensive effect significantly enhanced \u2013 avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4> \u2013

    Route <\/H4>IV, buccal, S\/L, oral, topical

    Rate of Administration <\/H4>10\u2013400 mcg\/minute (depends on response)

    Comments<\/H4>Compatible with sodium chloride 0.9% and glucose 5%Incompatible with polyvinylchloride bags

    OTHER INFORMATION <\/H4>Tolerance may develop; may be minimised by having nitrate-\u2018free\u2019 periodsIV infusions contain propylene glycol which can cause lactic acidosis \u2013 restrict to using for no more than 3 consecutive days.
    \n","protected":false},"excerpt":{"rendered":"

    Glyceryl trinitrate CLINICAL USE Vasodilator:Treatment and prophylaxis of angina, left<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4045","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4045"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4045\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}