{"id":4040,"date":"2025-03-31T18:11:56","date_gmt":"2025-03-31T18:11:56","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/gentamicin-txt\/"},"modified":"2025-03-31T18:11:56","modified_gmt":"2025-03-31T18:11:56","slug":"gentamicin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/gentamicin-txt\/","title":{"rendered":"Gentamicin.txt"},"content":{"rendered":"

Gentamicin <\/h1>\n

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>Once daily dose: 5\u20137 mg\/kg, dose is then adjusted according to levelsEndocarditis: 1 mg\/kg every 8 hours Intrathecal: 1\u20135 mg daily PD peritonitis: see local policy

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :477.6<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :0\u201330<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 90<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.3<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2\u20133\/20

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>30\u201370 3\u20135 mg\/kg daily and monitor levels10\u201330 2\u20133 mg\/kg daily and monitor levels5\u201310 2 mg\/kg every 48\u201372 hours according to levels

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed.
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: clearance is about 3 mL\/min. Dose as in GFR=5\u201310 mL\/min. Monitor levels<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR=5\u201310 mL\/min. Give after dialysis
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR=5\u201310 mL\/min. Give after dialysis
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose in GFR= 30\u201370 mL\/min according to severity of infection, and measure levels

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsBotulinum toxin: neuromuscular block enhanced \u2013 risk of toxicity\n
  • Ciclosporin: increased risk of nephrotoxicityCytotoxics: increased risk of nephrotoxicity and possibly of ototoxicity with platinum compounds\n
  • Diuretics: increased risk of ototoxicity with loop diureticsMuscle relaxants: effects of non- depolarising muscle relaxants and suxamethonium enhancedParasympathomimetics: antagonism of effect of neostigmine and pyridostigmine\n
  • Tacrolimus: increased risk of nephrotoxicity

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IV, IM, IP, intrathecal

    Rate of Administration <\/H4>Bolus IV: over not less than 3 minutes Short infusion: 20\u201330 minutes Once daily large infusions over 30\u2013 60 minutes

    Comments<\/H4>Can be added to sodium chloride or glucose 5%

    OTHER INFORMATION <\/H4>Concurrent penicillins may result in sub- therapeutic blood levelsMonitor blood levels. 1 hour post-dose peak levels must not exceed 10 mg\/L. Pre-dose trough levels should be less than 2 mg\/LIP therapy commonly used for PD peritonitis. Dose varies according to local protocol and whether
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: or APD dialysis. Monitoring of blood levels is advisable, as absorption is increased by inflamed peritoneumPotential nephrotoxicity of the drug may worsen residual renal functionLong-term concurrent use of gentamicin with teicoplanin causes additive ototoxicity.
    \n","protected":false},"excerpt":{"rendered":"

    Gentamicin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4040","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4040"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4040\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}