{"id":4013,"date":"2025-03-31T18:11:55","date_gmt":"2025-03-31T18:11:55","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/foscarnet-sodium-txt\/"},"modified":"2025-03-31T18:11:55","modified_gmt":"2025-03-31T18:11:55","slug":"foscarnet-sodium-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/foscarnet-sodium-txt\/","title":{"rendered":"Foscarnet sodium.txt"},"content":{"rendered":"

Foscarnet sodium <\/h1>\n

CLINICAL USE <\/H3>
\nAntiviral agent:Treatment and maintenance therapy of cytomegalovirus retinitis (CMV)Mucocutaneous herpes simplex infection (HSI)

DOSE IN NORMAL RENAL FUNCTION <\/H3>CMV: 60 mg\/kg every 8 hours induction dose for 2\u20133 weeks, then 60 mg\/kg daily, increase to 90\u2013120 mg\/kg if toleratedMucocutaneous herpes simplex infection: 40 mg\/kg every 8 hours

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :300<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :14\u201317<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 85<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.4\u20130.6<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2\u20134\/>100

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : 28 mg\/kg every 8 hours
  • 10 to 20 &nbsp &nbsp : 15 mg\/kg every 8 hours
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 6 mg\/kg every 8 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min. See \u2018Other Information\u2019<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min. See \u2018Other Information\u2019
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min. See \u2018Other Information\u2019
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR=10\u201320 mL\/min.

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Antivirals: avoid with lamivudine\n
  • Ciclosporin: may cause acute renal failure in combination

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Centrally (undiluted); peripherally (diluted)

    Rate of Administration <\/H4>Continuous infusion over 24 hours, or intermittent infusion over at least 60 minutes

    Comments<\/H4>If given peripherally dilute with glucose 5% or sodium chloride 0.9% to a concentration of 12 mg\/mL or lessAlternatively, piggy-back the undiluted foscarnet dose to 1 litre of a glucose 5% or sodium chloride 0.9% infusionIf given centrally, can be administered undiluted but additional fluids should be given to reduce the risk of nephrotoxicity

    OTHER INFORMATION <\/H4>Maintain adequate hydration to prevent renal toxicityMonitor serum calcium and magnesium Some units use full-dose ganciclovir and half-dose foscarnet concomitantly for treatment of resistant CMV disease
    \n","protected":false},"excerpt":{"rendered":"

    Foscarnet sodium CLINICAL USE Antiviral agent:Treatment and maintenance therapy of<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4013","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4013","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4013"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4013\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4013"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4013"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4013"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}