{"id":4000,"date":"2025-03-31T18:11:55","date_gmt":"2025-03-31T18:11:55","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/fluorouracil-txt\/"},"modified":"2025-03-31T18:11:55","modified_gmt":"2025-03-31T18:11:55","slug":"fluorouracil-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/fluorouracil-txt\/","title":{"rendered":"Fluorouracil.txt"},"content":{"rendered":"

Fluorouracil <\/h1>\n

CLINICAL USE <\/H3>
\nAntineoplastic agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>

IV infusion <\/H4>: 15 mg\/kg\/day to a total dose of 12\u201315 gIV bolus: 12 mg\/kg\/day for 3 days, then 6 mg\/kg on alternate days or 15 mg\/kg once a weekMaintenance: 5\u201315 mg\/kg once a week Intra-arterial infusion: 5\u20137.5 mg\/kg by continuous 24-hour infusionOral: 15 mg\/kg weekly; maximum 1 g in a dayOr consult relevant local chemotherapy protocol

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :130.1<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :10<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 15<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.25\u20130.5<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :16 minutes\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Some removal likely. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anticoagulants: possibly enhances effect of coumarins\n
  • Antipsychotics: avoid concomitant use with clozapine, increased risk of agranulocytosisMetronidazole and cimetidine inhibit metabolism (increased toxicity)Temoporfin: increased skin photosensitivity with topical fluorouracil

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Consult relevant local protocol

    Route <\/H4>

    IV infusion <\/H4> intermittent or continuous, IV injection, intra-arterial, oral, topical

    Rate of Administration <\/H4>30\u201360 minutes, 4 hours or as a continuous infusion over 24 hours or consult relevant local protocol

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Use ideal body weight in patients showing obesity, ascites, and oedemaRoche recommends decreasing the initial dose by one-third to one-half in patients with impaired hepatic or renal functionDistributed throughout the body water, activated in target cells, most of dose (80%) is metabolised by the liver, 60\u201380% is excreted as respiratory CO2 and 2\u20133% by the biliary systemFollowing a single IV dose, approximately 15% is excreted unchanged in the urine.
    \n","protected":false},"excerpt":{"rendered":"

    Fluorouracil CLINICAL USE Antineoplastic agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-4000","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=4000"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/4000\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=4000"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=4000"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=4000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}