{"id":3996,"date":"2025-03-31T18:11:55","date_gmt":"2025-03-31T18:11:55","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/flucytosine-txt\/"},"modified":"2025-03-31T18:11:55","modified_gmt":"2025-03-31T18:11:55","slug":"flucytosine-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/flucytosine-txt\/","title":{"rendered":"Flucytosine.txt"},"content":{"rendered":"

Flucytosine <\/h1>\n

CLINICAL USE <\/H3>
\nAntifungal agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>100\u2013200 mg\/kg per day in 4 divided doses

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :129.1<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :2\u20134<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 90<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.65\u20130.91<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3\u20136\/75\u2013200

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>20\u201340 50 mg\/kg 12 hourly
  • 10 to 20 &nbsp &nbsp : 50 mg\/kg 24 hourly
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 50 mg\/kg then dose according to levels. Dose of 0.5\u20131 g daily is usually adequate

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Give 50 mg\/kg daily in 4 divided doses. Monitor levels<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min, given post dialysis. Monitor trough level pre dialysis, and reduce post-dialysis dose accordingly
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min, given post dialysis. Monitor trough level pre dialysis, and reduce post-dialysis dose accordingly
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Give dose as in GFR 10 to 20 mL\/min and monitor blood levels, pre dose

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsCytarabine: concentration of flucytosine possibly reduced

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IV peripherally through a blood filter

    Rate of Administration <\/H4>20\u201340 minutes

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Monitor blood levels 24 hours after therapy commences. Pre-dose level 25\u201350 mg\/L is usually adequate. Do not exceed 80 mg\/L250 mL intravenous flucytosine infusion contains 34.5 mmol sodiumBone marrow suppression more common in patients with renal impairmentTablets available on named patient basis onlyCan be given IP at a dose of 50 mg\/L
    \n","protected":false},"excerpt":{"rendered":"

    Flucytosine CLINICAL USE Antifungal agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3996","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3996","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3996"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3996\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3996"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3996"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3996"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}