{"id":3991,"date":"2025-03-31T18:11:55","date_gmt":"2025-03-31T18:11:55","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/filgrastim-txt\/"},"modified":"2025-03-31T18:11:55","modified_gmt":"2025-03-31T18:11:55","slug":"filgrastim-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/filgrastim-txt\/","title":{"rendered":"Filgrastim.txt"},"content":{"rendered":"

Filgrastim <\/h1>\n

CLINICAL USE <\/H3>
\nRecombinant human granulocyte-colony stimulating factor (rhG-CSF):Treatment of neutropenia

DOSE IN NORMAL RENAL FUNCTION <\/H3>0.5\u20131.2 MU\/kg\/day according to indication and patient response

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :18 800<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Very high<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 0<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.15<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3.5\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function and titrate dose to response
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function and titrate dose to response
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function and titrate dose to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR=10\u201320 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • None known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IV, SC

    Rate of Administration <\/H4>IV: Over 30 minutes or continuous IV infusion over 24 hoursSC: Can give as continuous SC infusion over 24 hours

    Comments<\/H4>IV: Dilute with glucose 5% ONLY; minimum concentration 0.2 MU per mL \u2013 add Human Serum Albumin if concentration is less than 1.5 MU per mLSC: Continuous infusion \u2013 dilute with 20 mL of glucose 5%Dilute Neupogen may be adsorbed to glass and plastic materials \u2013 follow recommendations for dilution

    OTHER INFORMATION <\/H4>One very small study (2\u20133 patients) concluded that body clearance of filgrastim was not affected by any degree of renal impairment
    \n","protected":false},"excerpt":{"rendered":"

    Filgrastim CLINICAL USE Recombinant human granulocyte-colony stimulating factor (rhG-CSF):Treatment of<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3991","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3991"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3991\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3991"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3991"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}