{"id":3956,"date":"2025-03-31T18:11:54","date_gmt":"2025-03-31T18:11:54","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/esomeprazole-txt\/"},"modified":"2025-03-31T18:11:54","modified_gmt":"2025-03-31T18:11:54","slug":"esomeprazole-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/esomeprazole-txt\/","title":{"rendered":"Esomeprazole.txt"},"content":{"rendered":"

Esomeprazole<\/h1>\n

CLINICAL USE <\/H3>
\nGastric acid suppression

DOSE IN NORMAL RENAL FUNCTION <\/H3>20\u201340 mg dailyZollinger-Ellison syndrome: 80\u2013160 mg daily (doses >80 mg given in divided doses)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :345.4<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :97<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <1<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.22<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1.3\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anticoagulants: effect of coumarins possibly enhanced\n
  • Anti-epileptics: effects of phenytoin enhanced\n
  • Antivirals: reduced atazanavir concentration \u2013 avoid concomitant use

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>5 mL sodium chloride 0.9%

    Route <\/H4>Oral, IV

    Rate of Administration <\/H4>Bolus: over 3 minutes Infusion: 10\u201330 minutes

    Comments<\/H4>Dilute with up to 100 mL sodium chloride 0.9%

    OTHER INFORMATION <\/H4>Can be dispersed in half a glass of non-carbonated water. Stir well until it disintegrates; the liquid with pellets should be drunk immediately or within 30 minutes of preparation. The glass should then be rinsed with water which should also be drunkDo not crush or chew
    \n","protected":false},"excerpt":{"rendered":"

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