{"id":3915,"date":"2025-03-31T18:11:52","date_gmt":"2025-03-31T18:11:52","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/diltiazem-hdrochoride-txt\/"},"modified":"2025-03-31T18:11:52","modified_gmt":"2025-03-31T18:11:52","slug":"diltiazem-hdrochoride-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/diltiazem-hdrochoride-txt\/","title":{"rendered":"Diltiazem hdrochoride.txt"},"content":{"rendered":"

Diltiazem hdrochoride<\/h1>\n

CLINICAL USE <\/H3>
\nAnalgesia

DOSE IN NORMAL RENAL FUNCTION <\/H3>Oral: 30 mg every 4\u20136 hrsSC\/IM: up to 50 mg every 4\u20136 hrs

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :451.5<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :No data<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 13\u201322<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :1.1<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3.5\u20135\/>6

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Use small doses and titrate to response
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Use small doses and titrate to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in GFR 10 to 20 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral, IM, SC

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Increased and prolonged effect in renal impairment, enhancing respiratory depression and constipationIncreased CNS sensitivity in renal impairment. Accumulation of active metabolites can occur \u2013 cautionEffects can be reversed by naloxone dihydrocodeine tartrate.
    \n","protected":false},"excerpt":{"rendered":"

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