{"id":3911,"date":"2025-03-31T18:11:52","date_gmt":"2025-03-31T18:11:52","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/diazepam-txt\/"},"modified":"2025-03-31T18:11:52","modified_gmt":"2025-03-31T18:11:52","slug":"diazepam-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/diazepam-txt\/","title":{"rendered":"Diazepam.txt"},"content":{"rendered":"

Diazepam<\/h1>\n

CLINICAL USE <\/H3>
\nBenzodiazepine:Perioperative sedation (IV) Anxiolytic Muscle relaxant Status epilepticus

DOSE IN NORMAL RENAL FUNCTION <\/H3>Pre-med: Oral: 5 mg, IV:
  • 10 to 20 &nbsp &nbsp : mg or 100\u2013200 mcg\/kg; PR: 500 mcg\/kg repeated after 12 hours as rectal solution Anxiety: Oral: 2 mg 3 times a day, increasing if necessary to 15\u201330 mg daily in divided doses; PR: 10\u201330 mg daily in divided dosesIM\/IV: 5\u201310 mg repeated after not less than 4 hoursInsomnia: 5\u201315 mg at night Status epilepticus: IV: 10 mg, repeated after 10 minutes if required; PR: 500 mcg\/kg

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :284.7<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :95\u201399<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <1<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.95\u20132<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :24\u201348\/Increased

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Use small doses and titrate to response
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Use small doses and titrate to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR=10\u201320 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAntibacterials: metabolism enhanced by rifampicin; metabolism inhibited by isoniazidAntipsychotics: increased sedative effects; increased risk of hypotension, bradycardia and respiratory depression with parenteral diazepam and IM olanzapine; concentration of zotepine increasedAntivirals: increased risk of prolonged sedation with amprenavir; concentration possibly increased by ritonavirSodium oxybate: enhanced effects of sodium oxybate \u2013 avoid

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>IV injection, infusion, oral, PR

    Rate of Administration <\/H4>5 mg (1 mL)\/minute

    Comments<\/H4>Injection can be mixed with sodium chloride 0.9% or glucose 5% to 40 mg in 500 mL

    OTHER INFORMATION <\/H4>Active metabolites renally excreted; therefore accumulate in renal impairmentIncreased cerebral sensitivity in renal impairment which may result in excessive sedation and encephalopathyAlways have flumazenil available to reverse effectProtein binding decreased in ERF Volume of distribution increased in ERF IV emulsion formulation (Diazemuls) less likely to cause thrombophlebitis
    \n","protected":false},"excerpt":{"rendered":"

    Diazepam CLINICAL USE Benzodiazepine:Perioperative sedation (IV) Anxiolytic Muscle relaxant Status<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3911","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3911","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3911"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3911\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3911"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3911"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3911"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}