{"id":3907,"date":"2025-03-31T18:11:52","date_gmt":"2025-03-31T18:11:52","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/dexamethasone-txt\/"},"modified":"2025-03-31T18:11:52","modified_gmt":"2025-03-31T18:11:52","slug":"dexamethasone-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/dexamethasone-txt\/","title":{"rendered":"Dexamethasone.txt"},"content":{"rendered":"

Dexamethasone<\/h1>\n

CLINICAL USE <\/H3>
\nCorticosteroid:Cerebral oedema Suppression of inflammatory and allergic disordersRheumatic disease Congenital adrenal hyperplasia Anti-emetic (unlicensed indication)

DOSE IN NORMAL RENAL FUNCTION <\/H3>Cerebral oedema: 10 mg IV followed by 4 mg IM every 6 hoursRheumatic disease: intra-articular, intrasynovial: 0.4\u20134 mg \u2014(as dexamethasone phosphate)soft tissue infiltration: 2\u20136 mg \u2014Oral: 0.5\u201310 mg daily, IV\/IM: 0.5\u201324 mg

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :392.5 (472.4 as phosphate)<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :77<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 65<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.8\u20131<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3.5\u20134.5\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Removal unlikely. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAntibacterials: metabolism accelerated by rifampicin; metabolism possibly inhibited by erythromycinAnticoagulants: efficacy of coumarins may be alteredAnti-epileptics: metabolism accelerated by carbamazepine, barbiturates, phenytoin and primidoneAntifungals: increased risk of hypokalaemia with amphotericin \u2013 avoid concomitant use; metabolism possibly inhibited by itraconazole and ketoconazole; caspofungin concentration possibly reduced (may need to increase dose). Antivirals: concentration of indinavir, lopinavir and saquinavir possibly reduced; concentration possibly increased by ritonavirCiclosporin: rare reports of convulsions in patients on ciclosporin and high-dose corticosteroidsCytotoxics: increased risk of haematological toxicity with methotrexateDiuretics: enhanced hypokalaemic effects of acetazolamide, loop diuretics and thiazide diureticsVaccines: high dose corticosteroids can impair immune response to vaccines; avoid concomitant use with live vaccines

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral, IV, IM, intra-articular, intrasynovial

    Rate of Administration <\/H4>IV slowly over not less than 5 minutes. If underlying cardiac pathology, infusion over 20\u201330 minutes advised

    Comments<\/H4>\u2013

    OTHER INFORMATION <\/H4>Dexamethasone sodium phosphate 1.3 mg = dexamethasone 1 mg750 mcg of dexamethasone is equivalent to 5 mg prednisolone Injection solution can be administered orally or via naso-gastric tubeTablets will disperse in water
    \n","protected":false},"excerpt":{"rendered":"

    Dexamethasone CLINICAL USE Corticosteroid:Cerebral oedema Suppression of inflammatory and allergic<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3907","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3907","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3907"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3907\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3907"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3907"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3907"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}