{"id":3906,"date":"2025-03-31T18:11:52","date_gmt":"2025-03-31T18:11:52","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/desmopressin-txt\/"},"modified":"2025-03-31T18:11:52","modified_gmt":"2025-03-31T18:11:52","slug":"desmopressin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/desmopressin-txt\/","title":{"rendered":"Desmopressin.txt"},"content":{"rendered":"

Desmopressin<\/h1>\n

CLINICAL USE <\/H3>
\nDiabetes insipidus Nocturnal enuresis Post-biopsy bleeding (unlicensed indication)Pre-biopsy prophylaxis (unlicensed indication)

DOSE IN NORMAL RENAL FUNCTION <\/H3>Diabetes insipidus: Oral: 0.2\u20131.2 mg daily in 3 divided doses. IV: 1\u20134 mcg daily. Inhaled: 10\u201340 mcg in 1 or 2 divided doses. Sub-lingual: 120\u2013720 mcg dailyNocturnal enuresis: Oral: 200\u2013400 mcg at bedtime, Biopsy: Males \u2013 16 mcg; Females \u2013 12 mcg or 300\u2013400 nanograms\/kg Pre-biopsy prophylaxis in uraemic patients: 20 mcg (IV) over 30 minutes

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :1069.2<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :0<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 45<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.2\u20130.41<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :Inhaled: 55 minutes; Oral: 2.8 hours; IV: 51\u2013158 minutes\/\u2013

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Unlikely to be dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Dilute dose to 50 mL with sodium chloride 0.9%

    Route <\/H4>IV, intranasally, oral, SC, IM, SL

    Rate of Administration <\/H4>Over 20\u201360 minutes

    Comments<\/H4>Do not inject at a faster rate \u2013 greater risk of tachyphylaxisIn patients with ischaemic heart disease, infuse more slowly \u2013 increased risk of acute ischaemic event

    OTHER INFORMATION <\/H4>Emergency treatment of more generalised bleeding unresponsive to normal treatments: 0.1\u20130.5 micrograms\/kg 4 times a day + IV conjugated oestrogens (premarin) 0.6 mg\/kg\/day for up to 5 days DDAVP works as a haemostatic by stimulating factor VIII production Onset of action less than 1 hour. Duration of effect 4\u20138 hours
    \n","protected":false},"excerpt":{"rendered":"

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