{"id":3900,"date":"2025-03-31T18:11:52","date_gmt":"2025-03-31T18:11:52","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/deferasirox-txt\/"},"modified":"2025-03-31T18:11:52","modified_gmt":"2025-03-31T18:11:52","slug":"deferasirox-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/deferasirox-txt\/","title":{"rendered":"Deferasirox.txt"},"content":{"rendered":"

Deferasirox<\/h1>\n

CLINICAL USE <\/H3>
\nTreatment of iron overload

DOSE IN NORMAL RENAL FUNCTION <\/H3>10\u201330 mg\/kg once daily rounded to the nearest whole tablet

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :373.4<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :99<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 8<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :14 litres<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :8\u201316

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Avoid. See \u2018Other Information\u2019
  • 10 to 20 &nbsp &nbsp : Avoid. See \u2018Other Information\u2019
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Avoid. See \u2018Other Information\u2019

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Unlikely to be dialysed. Avoid<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Avoid
  • HDF\/high flux &nbsp :Dialysed. Avoid
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unlikely to be dialysed. Avoid

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAluminium-containing antacids: avoid concomitant useOther nephrotoxic agents: avoid concomitant therapy

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Take on an empty stomach Disperse in a glass of water, orange or apple juice

    OTHER INFORMATION <\/H4>Increased risk of potentially fatal renal failure and cytopenias in patients with other comorbidities who also had an advanced haematological condition. www.medscape.com\/viewarticle\/557118During clinical trials, increases in serum creatinine of >33% on 2 consecutive occasions (sometimes above the upper limit of the normal range) occurred in about 36% of patients. These were dose-dependent. Cases of acute renal failure have been reported following post-marketing use of deferasiroxPatients with pre-existing renal conditions and patients who are receiving medicinal products that depress renal function may be more at risk of complicationsTests for proteinuria should be performed monthly. Other markers of renal tubular function may also be monitored (e.g. glycosuria in non-diabetics and low levels of serum potassium, phosphate, magnesium or urate, phosphaturia, aminoaciduria)If, despite dose reduction and interruption, the serum creatinine remains significantly elevated and there is also persistent abnormality in another marker of renal function (e.g. proteinuria, Fanconi\u2019s Syndrome), the patient should be referred to a renal specialist, and further specialised investigations (such as renal biopsy) may be considered
    \n","protected":false},"excerpt":{"rendered":"

    Deferasirox CLINICAL USE Treatment of iron overload DOSE IN NORMAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3900","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3900"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3900\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3900"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3900"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}