{"id":3863,"date":"2025-03-31T18:11:51","date_gmt":"2025-03-31T18:11:51","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/colestyramine-txt\/"},"modified":"2025-03-31T18:11:51","modified_gmt":"2025-03-31T18:11:51","slug":"colestyramine-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/colestyramine-txt\/","title":{"rendered":"Colestyramine.txt"},"content":{"rendered":"

Colestyramine <\/h1>\n

CLINICAL USE <\/H3>
\nHyperlipidaemias Pruritus associated with partial biliary obstruction and primary biliary cirrhosisDiarrhoeal disorders

DOSE IN NORMAL RENAL FUNCTION <\/H3>Lipid reduction: 12\u201324 g daily (in single or up to 4 divided doses). Maximum 36 g dailyPruritus: 4\u20138 g daily Diarrhoeal disorders: 12\u201324 g daily. Maximum 36 g daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :\u2013<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :0<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 0<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :Not absorbed<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :Not absorbed

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in normal renal function
  • HDF\/high flux &nbsp :Not dialysed. Dose as in normal renal function
  • CAV\/VVHD &nbsp &nbsp &nbsp:Not dialysed. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAnticoagulants: effect of coumarins and phenindione may be enhanced or reducedCiclosporin: may interact unpredictably with ciclosporin. Take ciclosporin at least 1 hour before or 4\u20136 hours after to prevent problems with absorptionLeflunomide: avoid concomitant use Raloxifene, thyroid hormones, bile acids, valproate, cardiac glycosides and mycophenolate mofetil: absorption reduced

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>Mix with water, or a suitable liquid such as fruit juice, and stir to a uniform consistencyMay also be mixed with skimmed milk, thin soups, apple sauce, etc

    Route <\/H4>Oral

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Do not take in dry form Administer other drugs at least one hour before or 4\u20136 hours after colestyraminePrepare powder immediately prior to administration

    OTHER INFORMATION <\/H4>Hyperchloraemic acidosis occasionally reported on prolonged use of colestyramineOn chronic use, an increased bleeding tendency may occur associated with vitamin K deficiency
    \n","protected":false},"excerpt":{"rendered":"

    Colestyramine CLINICAL USE Hyperlipidaemias Pruritus associated with partial biliary obstruction<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3863","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3863"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3863\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3863"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3863"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}