{"id":3857,"date":"2025-03-31T18:11:51","date_gmt":"2025-03-31T18:11:51","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/co-amoxiclav-txt\/"},"modified":"2025-03-31T18:11:51","modified_gmt":"2025-03-31T18:11:51","slug":"co-amoxiclav-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/co-amoxiclav-txt\/","title":{"rendered":"Co AMoXiCLAV.txt"},"content":{"rendered":"

Co amoxiclav<\/h1>\n

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>IV: 1.2 g every 8 hours (increasing to every 6 hours in severe infections) Oral: 375\u2013625 mg 3 times daily

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Amoxycillin: 365.4; clavulanic acid: 199.2<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Amoxycillin: 20; clavulanic acid: 25<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : Amoxycillin: 60; clavulanic acid: 40<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :Amoxycillin: 0.3; clavulanic acid: 0.3<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :Amoxycillin: 1\u20131.5\/7\u201320; clavulanic acid: 1\/3\u20134

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>30\u201350 Dose as in normal renal function 10\u201330 IV: 1.2 g every 12 hours Oral: Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : IV: 1.2 g stat followed by 600 mg every 8 hours or 1.2 g every 12 hours Oral: Dose as in normal renal function

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min <\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • HDF\/high flux &nbsp :Dialysed. Dose as in GFR
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Dose as in GFR=10\u201330 mL\/min

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAnticoagulants: effects of coumarins are potentially enhancedOral contraceptives: potentially reduced efficacyMethotrexate: reduced excretion thereby increasing risk of toxicity

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>600 mg with 10 mL water for injection; 1.2 g with 20 mL water for injection

    Route <\/H4>Oral, IV

    Rate of Administration <\/H4>IV bolus: over 3\u20134 minutes Infusion: infuse over 30\u201340 minutes in 50\u2013100 mL sodium chloride 0.9%

    Comments<\/H4>IV preparation is less stable in infusion solutions containing glucose, dextran or bicarbonate. May be injected into drip tubing over period of 3\u20134 minutesDo not mix with aminoglycosides

    OTHER INFORMATION <\/H4>CSM has advised that cholestatic jaundice may occur if treatment exceeds a period of 14 days or up to 6 weeks after treatment has been stopped. The incidence of cholestatic jaundice occurring with co-amoxiclav is higher in males than in females, and prevalent particularly in men over the age of 65 yearsThe probability of co-amoxiclav associated cholestatic jaundice is 6 times more common than with amoxicillin, and with higher doses of clavulanic acidEach 1.2 g vial contains: sodium 2.7 mmol, potassium 1 mmol
    \n","protected":false},"excerpt":{"rendered":"

    Co amoxiclav CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3857","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3857"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3857\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}