CAV\/VVHD      :Unknown dialysability. Dose as in GFR 10 to 20 mL\/min IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAnaesthetics: enhanced hypotensive effect Analgesics: avoid concomitant use with azapropazone; increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioidsAnti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval; increased risk of arrhythmias with flecainideAntibacterials: concentration possibly increased by erythromycin (possible increased risk of convulsions); concentration increased by ciprofloxacin; concentration possibly reduced by rifampicin; avoid concomitant use with chloramphenicol and sulphonamides (increased risk of agranulocytosis)Antidepressants: concentration possibly increased by citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline and venlafaxine (increased risk of toxicity); possibly increased CNS effects of MAOIs; possibly increased antimuscarinic effects with tricyclics; increased plasma level of tricyclicsAnti-epileptics: antagonises anticonvulsant effect; metabolism accelerated by carbamazepine and phenytoin; avoid concomitant use with drugs known to cause agranulocytosisAntimalarials: avoid concomitant use with artemether\/lumefantrineAntipsychotics: avoid concomitant use with depot formulations (cannot be withdrawn quickly if neutropenia occurs)Antivirals: concentration possibly increased by amprenavir; concentration increased by ritonavir \u2013 avoid concomitant useAnxiolytics and hypnotics: increased sedative effectsCytotoxics: increased risk of agranulocytosis \u2013 avoid concomitant useLithium: increased risk of extrapyramidal side effects and possibly neurotoxicityPenicillamine: increased risk of agranulocytosis \u2013avoid concomitant useSibutramine: increased risk of CNS toxicity \u2013 avoid concomitant use Ulcer-healing drugs: effects possibly enhanced by cimetidine; concentration possibly reduced by omeprazole. ADMINISTRATION <\/H3> Reconstition<\/H4>\u2013 Route <\/H4>Oral Rate of Administration <\/H4>\u2013Comments<\/H4>\u2013 OTHER INFORMATION <\/H4>Patient must be registered with appropriate company monitoring schemeAssociated with myocarditis (increased risk in the first 2 months) and cardiomyopathyPotentially fatal agranulocytosis and neutropenia have been reported. WCC has to be monitored at least weekly for the first 18 weeks then 2 weekly for weeks 18\u201352 and then at least 4 weeklyIncreased risk of side effects especially seizures in doses above 450 mg dailyRarely interstitial nephritis has been reported with clozapineDose in severe renal impairment taken from personal experience.
\n","protected":false},"excerpt":{"rendered":"
Clozapine CLINICAL USE Atypical antipsychotic:Schizophrenia Psychosis in Parkinson\u2019s disease DOSE<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3856","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3856","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3856"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3856\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3856"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3856"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3856"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}