CAV\/VVHD      :Unknown dialysability. Dose as in GFR=10\u201330 mL\/min IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAnti-arrhythmics: possibly increased disopyramide concentrationAntibacterials: increased rifabutin concentration \u2013 reduce rifabutin dose; clarithromycin concentration reduced by rifamycinsAnticoagulants: effect of coumarins potentially enhancedAntidepressants: avoid concomitant use with reboxetineAnti-epileptics: increased carbamazepine and phenytoin concentration. Antihistamines: metabolism of mizolastine inhibited \u2013 avoid concomitant useAntimalarials: avoid concomitant administration with artemether\/lumefantrineAntimuscarinics: avoid concomitant use with tolterodineAntipsychotics: increased risk of arrhythmias with pimozide and sertindole \u2013 avoid concomitant use; possibly increased quetiapine concentrationAntivirals: concentration of both drugs increased with atazanavir; increased risk of rash with efavirenz; oral clarithromycin reduces absorption of zidovudine; concentration increased by ritonavir and tipranavir, also concentration of tipranavir increased \u2013 reduce dose of clarithromycin in renal impairmentAnxiolytics: metabolism of midazolam inhibitedCalcium-channel blockers: possibly inhibits verapamil concentrationCiclosporin: increased ciclosporin concentration (although may take \u2245 5 days after starting clarithromycin before increase in ciclosporin levels is seen)Colchicine: treatment with both agents has been shown in a study to increase the risk of fatal colchicine toxicity, especially in patients with renal impairment.1 Diuretics: increased eplerenone concentration \u2013 avoid concomitant useErgot alkaloids: increase risk of ergotism \u2013 avoid concomitant use5 HT 1 agonists: increased eletriptan concentration \u2013 avoid concomitant useIvabradine: increased ivabradine concentration \u2013 avoid concomitant useLipid-lowering drugs: increased risk of myopathy with atorvastatin and simvastatin, avoid with simvastatin and max dose of atorvastatin 20 mg.2Sirolimus: possibly increased sirolimus concentration \u2013 avoid concomitant useTacrolimus: increased tacrolimus levels Theophylline: increased theophylline concentration. ADMINISTRATION <\/H3> Reconstition<\/H4>Add 10 mL water for injection to vial (500 mg). Add reconstituted product to 250 mL glucose 5% or sodium chloride 0.9%. (Stable in 100 mL, but more likely to cause phlebitis, pain and inflammation at the injection site) Route <\/H4> IV infusion <\/H4> into one of the larger proximal veinsNot to be administered by bolus or IM injection Rate of Administration <\/H4>Over 60 minutes Comments<\/H4>\u2013 OTHER INFORMATION <\/H4>Use with caution in renal or hepatic failure Oral bioavailability is 55% Patients with GFR <10 mL\/min, vomiting may be a problem with high doses
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Clarithromycin CLINICAL USE Antibacterial agent:Adjunct in treatment of duodenal ulcers<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3847","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3847"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3847\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}