{"id":3843,"date":"2025-03-31T18:11:51","date_gmt":"2025-03-31T18:11:51","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ciprofloxacin-txt\/"},"modified":"2025-03-31T18:11:51","modified_gmt":"2025-03-31T18:11:51","slug":"ciprofloxacin-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ciprofloxacin-txt\/","title":{"rendered":"Ciprofloxacin.txt"},"content":{"rendered":"

Ciprofloxacin<\/h1>\n

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>Oral: 250\u2013750 mg every 12 hoursIV: 100\u2013400 mg every 12 hours

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :331.3<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :20\u201340<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 40\u201370<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :2.5<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :3\u20135\/8

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : 50\u2013100% of normal dose
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : 50% of normal dose. (100% dose may be given for short periods under exceptional circumstances)

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Oral: 250 mg every 8\u201312 hours. IV: 200 mg every 12 hours<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Oral: 250\u2013500 mg every 12 hours. IV: 200 mg every 12 hours
  • HDF\/high flux &nbsp :Unknown dialysability. Oral: 250\u2013500 mg every 12 hours. IV: 200 mg every 12 hours
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. Oral: 500\u2013750 mg every 12 hours. IV: 200\u2013400 mg every 12 hours

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsAnalgesics: increased risk of convulsions with NSAIDs; avoid premedication with opioid analgesicsAnticoagulants: anticoagulant effect of coumarins enhancedAntidepressants: metabolism of duloxetine inhibitedAntimalarials: manufacturer of artemether with lumefantrine advises avoid concomitant useAntipsychotics: possibly increased concentration of olanzapine and clozapineCiclosporin: variable response; no interaction seen locally; some reports of increased nephrotoxicityMuscle relaxants: tizanidine concentration increased \u2013 avoid concomitant useTacrolimus: increased levels (anecdotally) Theophylline: possibly increased risk of convulsions; increased plasma levels of theophylline

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral, IV

    Rate of Administration <\/H4>Infusion: over 30\u201360 minutes

    Comments<\/H4>Swallow tablets whole, do not chew Do not take milk, iron preparations, indigestion remedies or phosphate binders at the same time as ciprofloxacin orally

    OTHER INFORMATION <\/H4>Intraperitoneal ciprofloxacin in
  • CAPD <\/LI>, dose range 25 mg\/L to 100 mg\/LIn
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp: peritonitis oral ciprofloxacin up to 500 mg twice daily may be administeredOral bioavailability is 70\u201380% Only very small amounts removed by dialysis
    \n","protected":false},"excerpt":{"rendered":"

    Ciprofloxacin CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3843","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3843"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3843\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}