{"id":3836,"date":"2025-03-31T18:11:50","date_gmt":"2025-03-31T18:11:50","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/cidofovir-txt\/"},"modified":"2025-03-31T18:11:50","modified_gmt":"2025-03-31T18:11:50","slug":"cidofovir-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/cidofovir-txt\/","title":{"rendered":"Cidofovir.txt"},"content":{"rendered":"

Cidofovir<\/h1>\n

CLINICAL USE <\/H3>
\nTreatment of CMV retinitis in patients with AIDS, if other agents are unsuitableTreatment of BK polyoma virus in transplant patients (unlicensed)

DOSE IN NORMAL RENAL FUNCTION <\/H3>5 mg\/kg weekly for 2 weeks then once every 2 weeks(See further information for BK polyoma virus treatment)

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :279.2<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :<6<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 80\u2013100<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.3\u20130.8<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :1.7\u20132.7\/16\u2013251

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>>55 Dose as in normal renal function<55 Avoid. See \u2018Other Information\u2019

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. 0.5 mg\/kg\/dose<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. 0.5 mg\/kg\/dose
  • HDF\/high flux &nbsp :Dialysed. 0.5 mg\/kg\/dose
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. 0.5 mg\/kg\/dose

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugsNone known

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>

    IV infusion <\/H4>

    Rate of Administration <\/H4>Over 60 minutes

    Comments<\/H4>Dilute in 100 mL sodium chloride 0.9%

    OTHER INFORMATION <\/H4>Always administer with oral probenecid and intravenous sodium chloride 0.9%Administer 2 hours before dialysis session to benefit from peak concentration without having delayed clearance52\u201375% of dose dialysed out with high- flux haemodialysisInformation for the treatment of BK polyoma virus in transplant patients is from Pittsburgh. Starting dose was 0.25 mg\/kg (if GFR<30 mL\/min) in 100 mL sodium chloride 0.9% administered over 1 hour, given every 10\u201314 days. Hydration pre- and post-dose with 1 litre of sodium chloride 0.9% if tolerated. If no change within 10\u201314 days increase to 0.3\u20130.5 mg\/kg; dose can be increased up to 1 mg\/kg depending on response and side effects. Most patients would need a cumulative dose of 1\u20131.5 mg\/kg. Initially use without probenecid. Monitor blood and urine samples for PCR measurement of viral load. The manufacturer advises to avoid in renal failure but theoretical doses, based on a 70 kg person, are suggested in the following paper
    \n","protected":false},"excerpt":{"rendered":"

    Cidofovir CLINICAL USE Treatment of CMV retinitis in patients with<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3836","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3836","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3836"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3836\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}