{"id":3832,"date":"2025-03-31T18:11:50","date_gmt":"2025-03-31T18:11:50","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/chlorpromazine-hydrochloride-txt\/"},"modified":"2025-03-31T18:11:50","modified_gmt":"2025-03-31T18:11:50","slug":"chlorpromazine-hydrochloride-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/chlorpromazine-hydrochloride-txt\/","title":{"rendered":"Chlorpromazine hydrochloride.txt"},"content":{"rendered":"

Chlorpromazine hydrochloride<\/h1>\n

CLINICAL USE <\/H3><\/p>\n
  • Anti-emetic\n
  • Anxiolytic\n
  • Antipsychotic\n
  • Hiccups

    DOSE IN NORMAL RENAL FUNCTION <\/H3>\n
  • Anti-emetic: Oral: 10\u201325 mg every 4\u20136 hours \u2014IM: 25\u201350 mg every 3\u20134 hours\n
  • Antipsychotic, anxiolytic: Oral: 25 mg every 8 hours (or 75 mg at \u2014night) initially; increase as necessary; usual maintenance dose 75\u2013300 mg daily (up to 1 g daily)\n
  • IM: 25\u201350 mg every 6\u20138 hours\n
  • \n
  • Induction of hypothermia: 25\u201350 mg every 6\u20138 hours\n
  • Hiccups: Oral: 25\u201350 mg every 6\u20138 hours\n
  • PR (unlicensed): 100 mg every 6\u20138 hours

    PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :355.3<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :95\u201398<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : <1<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :7\u2013201<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :23\u201337\/Unchanged

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>
  • 20 to 50 &nbsp &nbsp : Dose as in normal renal function
  • 10 to 20 &nbsp &nbsp : Dose as in normal renal function
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp : Start with small dose and increase according to response

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Not dialysed. Dose as in GFR <10 mL\/min<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Not dialysed. Dose as in GFR <10 mL\/min
  • HDF\/high flux &nbsp :Unknown dialysability. Dose as in GFR <10 mL\/min
  • CAV\/VVHD &nbsp &nbsp &nbsp:Unknown dialysability. Dose as in normal renal function

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anaesthetics: enhanced hypotensive effect\n
  • Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids\n
  • Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval; avoid concomitant use with amiodarone\n
  • Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin \u2013 avoid concomitant use\n
  • Antidepressants: increased level of tricyclics, possibly increased risk of ventricular arrhythmias and antimuscarinic side effectsAnticonvulsant: antagonises anticonvulsant effectAntimalarials: avoid concomitant use with artemether\/lumefantrineAntipsychotics: increased risk of ventricular arrhythmias with pimozide \u2013 avoid concomitant useAntivirals: concentration possibly increased with ritonavirAnxiolytics and hypnotics: increased sedative effectsAtomoxetine: increased risk of ventricular arrhythmiasBeta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalolDiuretics: enhanced hypotensive effect Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicityPentamidine: increased risk of ventricular arrhythmiasSibutramine: increased risk of CNS toxicity \u2013 avoid concomitant useUlcer-healing drugs: effects enhanced by cimetidine

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\u2013

    Route <\/H4>Oral, deep IM, PR (unlicensed)

    Rate of Administration <\/H4>\u2013

    Comments<\/H4>Start with small doses in severe renal impairment due to increased cerebral sensitivity
    \n","protected":false},"excerpt":{"rendered":"

    Chlorpromazine hydrochloride CLINICAL USE Anti-emetic Anxiolytic Antipsychotic Hiccups DOSE IN<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3832","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3832"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3832\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3832"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3832"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}