{"id":3819,"date":"2025-03-31T18:11:50","date_gmt":"2025-03-31T18:11:50","guid":{"rendered":"https:\/\/kidneydiseaseclinic.net\/kdc\/ceftazidime-txt\/"},"modified":"2025-03-31T18:11:50","modified_gmt":"2025-03-31T18:11:50","slug":"ceftazidime-txt","status":"publish","type":"post","link":"https:\/\/kidneydiseaseclinic.net\/kdc\/ceftazidime-txt\/","title":{"rendered":"Ceftazidime.txt"},"content":{"rendered":"

Ceftazidime<\/h1>\n

CLINICAL USE <\/H3>
\nAntibacterial agent

DOSE IN NORMAL RENAL FUNCTION <\/H3>0.5\u20132 g every 8\u201312 hours Severe infections: 3 g every 12 hours Pseudomonal lung infections in cystic fibrosis: 100\u2013150 mg\/kg in 3 divided dosesSurgical prophylaxis: 1 g at induction

PHARMACOKINETICS <\/H3>
  • Molecular weight &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :637.7<\/li>\n
  • %Protein binding &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :
  • <10 &nbsp &nbsp &nbsp &nbsp &nbsp :<\/li>\n
  • %Excreted unchanged in urine &nbsp &nbsp : 80\u201390<\/li>\n

  • Volume of distribution (L\/kg) &nbsp &nbsp &nbsp :0.28\u20130.4<\/li>\n

  • half-life \u2013 normal\/ESRD (hrs)&nbsp &nbsp &nbsp :2\/13\u201325

    DOSE IN RENAL IMPAIRMENT <\/H3>

    GFR (mL\/MIN)<\/H4>31\u201350 1\u20132 g every 12 hours16\u201330 1\u20132 g every 24 hours6\u201315 500 mg \u2013 1 g every 24 hours<5 500 mg \u2013 1 g every 48 hours

    DOSE IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPIES <\/H3>
  • CAPD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp:Dialysed. 500 mg \u2013 1 g every 24 hours<\/p>\n
  • HD &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp &nbsp :Dialysed. 500 mg \u2013 1 g every 24\u201348 hours
  • HDF\/high flux &nbsp :Dialysed. 500 mg \u2013 1 g every 24\u201348 hours
  • CAV\/VVHD &nbsp &nbsp &nbsp:Dialysed. 2 g every 8 hours1 or 1\u20132 g every 12 hours1,2,3CVVhd\/HDFDialysed. 2 g every 12 hours3

    IMPORTANT DRUG INTERACTIONS <\/H3>Potentially hazardous interactions with other drugs\n
  • Anticoagulants: effects of coumarins may be enhanced\n
  • Ciclosporin: may cause increased ciclosporin levels

    ADMINISTRATION <\/H3>

    Reconstition<\/H4>\n
  • Amount of water for injection to be added to vials:\n
  • 1.5 mL to 500 mg vial for IM administration\n
  • 5 mL to 500 mg vial for IV injection\n
  • 3 mL to 1 g vial for IM administration\n
  • 10 mL to 1 g vial for IV injection \u2014

    Route <\/H4>IV\/IM rarely

    Rate of Administration <\/H4>Bolus: 3\u20134 minutes Infusion: over 30 minutes

    Comments<\/H4>May be given IP in fluid 50\u2013125 mg\/L fluid\n
  • Reconstituted solutions vary in colour, but this is quite normal\n
  • Compatible with most IV fluids, e.g. sodium chloride 0.9%, glucose-saline, glucose 5%

    OTHER INFORMATION <\/H4>\n
  • Volume of distribution increases with infection\n
  • In exceptional circumstances, patients on haemodialysis may be given a dose of 2 g, 3 times a week post HD
    \n","protected":false},"excerpt":{"rendered":"

    Ceftazidime CLINICAL USE Antibacterial agent DOSE IN NORMAL RENAL FUNCTION<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[7],"class_list":["post-3819","post","type-post","status-publish","format-standard","hentry","category-blog","tag-post-by-auto-php"],"_links":{"self":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/comments?post=3819"}],"version-history":[{"count":0,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/posts\/3819\/revisions"}],"wp:attachment":[{"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/media?parent=3819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/categories?post=3819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kidneydiseaseclinic.net\/kdc\/wp-json\/wp\/v2\/tags?post=3819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}